Warren S. Warren

Warren S. Warren

James B. Duke Distinguished Professor of Chemistry

Professor of Chemistry

Professor of Radiology (Joint)

Professor of Physics (Joint)

Member of the Duke Cancer Institute

Office Location: 
2217 French Science Center, Durham, NC 27708
Front Office Address: 
Box 90346, Durham, NC 27708-0346
(919) 660-1604


Our work focuses on the design and application of what might best be called novel pulsed techniques, using controlled radiation fields to alter dynamics. The heart of the work is chemical physics, and most of what we do is ultrafast laser spectroscopy or nuclear magnetic resonance. It generally involves an intimate mixture of theory and experiment: recent publications are roughly an equal mix of pencil- and-paper theory, computer calculations with our workstations, and experiments. Collaborations also play an important role, particularly for medical applications.

Education & Training

  • Ph.D., University of California - Berkeley 1980

  • M.S., University of California - Berkeley 1979

Selected Grants

Novel Techniques in Nonlinear Optical Microscopy for Improving Melanoma Diagnosis awarded by National Institutes of Health (Principal Investigator). 2013 to 2015

Intermolecular Multiple-Quantum Coherence Effects in MRI awarded by National Institutes of Health (Principal Investigator). 2005 to 2015

Dynamics and Characterization of Long-Lived Hyperpolarized Molecules in Magnetic Resonance awarded by National Science Foundation (Principal Investigator). 2011 to 2015

Agilent Direct Drive 9.4T MRS/MRI Console awarded by National Institutes of Health (Major User). 2012 to 2013

Novel Magnetic Resonance Approach to Detect BAT Distribution and Temperature awarded by National Institutes of Health (Investigator). 2010 to 2012

Imaging Nonlinear Absorption of Biomarkers for Improved Detection of Melanoma awarded by National Institutes of Health (Principal Investigator). 2009 to 2012


Thompson, Andrew, et al. “Dual-wavelength pump-probe microscopy analysis of melanin composition.Scientific Reports, vol. 6, Nov. 2016, p. 36871. Epmc, doi:10.1038/srep36871. Full Text

Warren, Warren S. “Obituary: Ahmed Hassan Zewail (1946-2016).Nature, vol. 537, no. 7619, Sept. 2016, p. 168. Epmc, doi:10.1038/537168a. Full Text

Villafana, Tana E., et al. “High-resolution, three-dimensional imaging of pigments and support in paper and textiles.” Journal of Cultural Heritage, vol. 20, Elsevier BV, July 2016, pp. 583–88. Crossref, doi:10.1016/j.culher.2016.02.003. Full Text

Logan, Angus W. J., et al. “Hyperpolarization of Nitrogen-15 Schiff Bases by Reversible Exchange Catalysis with para-Hydrogen.Chemistry (Weinheim an Der Bergstrasse, Germany), vol. 22, no. 31, July 2016, pp. 10777–81. Epmc, doi:10.1002/chem.201602393. Full Text

Barskiy, Danila A., et al. “Over 20% (15)N Hyperpolarization in Under One Minute for Metronidazole, an Antibiotic and Hypoxia Probe.Journal of the American Chemical Society, vol. 138, no. 26, July 2016, pp. 8080–83. Epmc, doi:10.1021/jacs.6b04784. Full Text

Shchepin, Roman V., et al. “15N Hyperpolarization of Imidazole-15N2 for Magnetic Resonance pH Sensing via SABRE-SHEATH.Acs Sensors, vol. 1, no. 6, June 2016, pp. 640–44. Epmc, doi:10.1021/acssensors.6b00231. Full Text Open Access Copy

Davis, Ryan M., et al. “Multi-spin echo spatial encoding provides three-fold improvement of temperature precision during intermolecular zero quantum thermometry.Magnetic Resonance in Medicine, vol. 75, no. 5, May 2016, pp. 1958–66. Epmc, doi:10.1002/mrm.25789. Full Text

Theis, Thomas, et al. “Direct and cost-efficient hyperpolarization of long-lived nuclear spin states on universal (15)N2-diazirine molecular tags.Science Advances, vol. 2, no. 3, Mar. 2016, p. e1501438. Epmc, doi:10.1126/sciadv.1501438. Full Text Open Access Copy

Fischer, Martin C., et al. “Invited Review Article: Pump-probe microscopy.” Review of Scientific Instruments, vol. 87, no. 3, AIP Publishing, Mar. 2016, pp. 031101–031101. Crossref, doi:10.1063/1.4943211. Full Text

Zhou, Zijian, et al. “Accessing long lived (1)H states via (2)H couplings.Journal of Magnetic Resonance (San Diego, Calif. : 1997), vol. 263, Feb. 2016, pp. 108–15. Epmc, doi:10.1016/j.jmr.2015.12.020. Full Text


Villafaña, T. E., et al. “Historical pigments revealed by pump-probe microscopy.” Laser Science, Ls 2012, 2012.

Warren, Warren S. “Applications of novel nonlinear imaging: From melanoma diagnosis to art restoration.” Abstracts of Papers of the American Chemical Society, vol. 244, AMER CHEMICAL SOC, 2012.

Li, B., et al. “Homodyne near-degenerate four-wave-mixing microscopy for graphene imaging and biomedical applications.” Cleo: Science and Innovations, Cleo Si 2012, 2012. Scopus, doi:10.1364/cleo_si.2012.cf1b.3. Full Text

Wilson, J. W., et al. “Nonlinear cross-phase modulation microscopy using spectral shifting.” Cleo: Applications and Technology, Cleo at 2012, 2012. Scopus, doi:10.1364/cleo_at.2012.jw3g.2. Full Text

Samineni, P., et al. “Pump-probe microscopy of pigments used in historical art.” Cleo: Science and Innovations, Cleo Si 2012, 2012. Scopus, doi:10.1364/cleo_si.2012.cf1b.1. Full Text

Simpson, M. J., et al. “Pump-probe imaging of melanin identifies metastatic potential of melanoma.” Frontiers in Optics, Fio 2012, 2012. Scopus, doi:10.1364/fio.2012.ftu1c.5. Full Text

Li, B., et al. “Optimizing shape of femtosecond laser pulses for homodyne detection of nonlinear optical signals.” Optics Infobase Conference Papers, 2011.

Fischer, M. C., et al. “Accessing nonlinear phase contrast in biological tissue using femtosecond laser pulse shaping.” Optics Infobase Conference Papers, 2011.

Samineni, P., et al. “Cross-phase modulation microscopy.” Optics Infobase Conference Papers, 2011.

Claytor, K., et al. “Femtosecond pulse shaping enables nonlinear imaging in highly scattering materials.” Optics Infobase Conference Papers, 2011.