Warren S. Warren

Warren S. Warren

James B. Duke Distinguished Professor of Chemistry

Professor of Chemistry

Professor of Radiology (Joint)

Professor of Physics (Joint)

Member of the Duke Cancer Institute

Office Location: 
2217 French Science Center, Durham, NC 27708
Front Office Address: 
Box 90346, Durham, NC 27708-0346
Phone: 
(919) 660-1604

Overview

Our work focuses on the design and application of what might best be called novel pulsed techniques, using controlled radiation fields to alter dynamics. The heart of the work is chemical physics, and most of what we do is ultrafast laser spectroscopy or nuclear magnetic resonance. It generally involves an intimate mixture of theory and experiment: recent publications are roughly an equal mix of pencil- and-paper theory, computer calculations with our workstations, and experiments. Collaborations also play an important role, particularly for medical applications.

Education & Training

  • Ph.D., University of California, Berkeley 1980

  • M.S., University of California, Berkeley 1979

Selected Grants

CMBI & NCMA Art Imaging Initiative awarded by (Principal Investigator). 2013 to 2018

Improving Melanoma Diagnosis with Pump-Probe Optical Imaging awarded by National Institutes of Health (Principal Investigator). 2013 to 2017

Coupling the Dynamics of Molecules and Spins in Nuclear Magnetic Resonance for Imaging and Oil Borehole Applications awarded by American Chemical Society (Co-Principal Investigator). 2015 to 2017

Multi-modality optical molecular imaging for melanoma tumor margin assessment awarded by National Institutes of Health (Principal Investigator). 2014 to 2017

Sensitive and Specific Molecular Imaging of Pulmonary Nodules awarded by National Institutes of Health (Co Investigator). 2010 to 2016

Structural Biology and Biophysics Training Program awarded by National Institutes of Health (Mentor). 1994 to 2015

Novel Techniques in Nonlinear Optical Microscopy for Improving Melanoma Diagnosis awarded by National Institutes of Health (Principal Investigator). 2013 to 2015

Intermolecular Multiple-Quantum Coherence Effects in MRI awarded by National Institutes of Health (Principal Investigator). 2005 to 2015

Pages

Shen, Kun, et al. “Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long-Lived SABRE-Induced Hyperpolarization.Angewandte Chemie (International Ed. in English), vol. 56, no. 40, Sept. 2017, pp. 12112–16. Epmc, doi:10.1002/anie.201704970. Full Text

Shchepin, Roman V., et al. “Toward Hyperpolarized 19 F Molecular Imaging via Reversible Exchange with Parahydrogen.Chemphyschem : A European Journal of Chemical Physics and Physical Chemistry, vol. 18, no. 15, Aug. 2017, pp. 1961–65. Epmc, doi:10.1002/cphc.201700594. Full Text

Wilson, Jesse W., et al. “Comparison of pump-probe and hyperspectral imaging in unstained histology sections of pigmented lesions.” Biomedical Optics Express, vol. 8, no. 8, The Optical Society, Aug. 2017, pp. 3882–3882. Crossref, doi:10.1364/boe.8.003882. Full Text

Zhou, Zijian, et al. “Long-Lived 13C2 Nuclear Spin States Hyperpolarized by Parahydrogen in Reversible Exchange at Microtesla Fields.The Journal of Physical Chemistry Letters, vol. 8, no. 13, July 2017, pp. 3008–14. Epmc, doi:10.1021/acs.jpclett.7b00987. Full Text

Colell, Johannes F. P., et al. “Direct Hyperpolarization of Nitrogen-15 in Aqueous Media with Parahydrogen in Reversible Exchange.Journal of the American Chemical Society, vol. 139, no. 23, June 2017, pp. 7761–67. Epmc, doi:10.1021/jacs.7b00569. Full Text

Barskiy, Danila A., et al. “The Absence of Quadrupolar Nuclei Facilitates Efficient 13 C Hyperpolarization via Reversible Exchange with Parahydrogen.Chemphyschem : A European Journal of Chemical Physics and Physical Chemistry, vol. 18, no. 12, June 2017, pp. 1493–98. Epmc, doi:10.1002/cphc.201700416. Full Text

Robles, Francisco E., et al. “Label-Free Imaging of Female Genital Tract Melanocytic Lesions With Pump-Probe Microscopy: A Promising Diagnostic Tool.J Low Genit Tract Dis, vol. 21, no. 2, Apr. 2017, pp. 137–44. Pubmed, doi:10.1097/LGT.0000000000000290. Full Text

Colell, Johannes F. P., et al. “Generalizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange.The Journal of Physical Chemistry. C, Nanomaterials and Interfaces, vol. 121, no. 12, Mar. 2017, pp. 6626–34. Epmc, doi:10.1021/acs.jpcc.6b12097. Full Text

Robles, Francisco E., et al. “Stimulated Raman scattering spectroscopic optical coherence tomography.” Optica, vol. 4, no. 2, The Optical Society, Feb. 2017, pp. 243–243. Crossref, doi:10.1364/optica.4.000243. Full Text

Thompson, Andrew, et al. “Dual-wavelength pump-probe microscopy analysis of melanin composition.Scientific Reports, vol. 6, Nov. 2016, p. 36871. Epmc, doi:10.1038/srep36871. Full Text

Pages

Wilson, J. W., et al. “Optical clearing and multiphoton imaging of paraffin-embedded specimens.” Progress in Biomedical Optics and Imaging  Proceedings of Spie, vol. 8588, 2013. Scopus, doi:10.1117/12.2003155. Full Text

Robles, F. E., et al. “Adapting phasor analysis for nonlinear pump-probe microscopy.” Progress in Biomedical Optics and Imaging  Proceedings of Spie, vol. 8589, 2013. Scopus, doi:10.1117/12.2002600. Full Text

Degan, Simone, et al. “Abstract 3914:In vivolabel-free examination of early-stage melanoma formation.Tumor Biology, American Association for Cancer Research, 2013. Crossref, doi:10.1158/1538-7445.am2013-3914. Full Text

Robles, F. E., et al. “Pump-probe nonlinear phase dispersion spectroscopy: Molecular contrast of pigmented and non-pigmented samples.” Optics Infobase Conference Papers, 2013. Scopus, doi:10.1364/fio.2013.fw1d.3. Full Text

Li, B., et al. “Homodyne near-degenerate four-wave-mixing microscopy for graphene imaging and biomedical applications.” 2012 Conference on Lasers and Electro Optics, Cleo 2012, 2012.

Wilson, J. W., et al. “Nonlinear cross-phase modulation microscopy using spectral shifting.” 2012 Conference on Lasers and Electro Optics, Cleo 2012, 2012.

Samineni, P., et al. “Pump-probe microscopy of pigments used in historical art.” 2012 Conference on Lasers and Electro Optics, Cleo 2012, 2012.

Wilson, J. W., et al. “Nonlinear cross-phase modulation microscopy using spectral shifting.” Cleo: Applications and Technology, Cleo at 2012, 2012.

Samineni, P., et al. “Pump-probe microscopy of pigments used in historical art.” Cleo: Science and Innovations, Cleo Si 2012, 2012.

Wilson, J. W., et al. “Nonlinear cross-phase modulation microscopy using spectral shifting.” Optics Infobase Conference Papers, 2012.

Pages