Warren S. Warren

Warren S. Warren

James B. Duke Professor of Chemistry

Office Location: 
2217 French Science Center, Durham, NC 27708
Front Office Address: 
Box 90346, Durham, NC 27708-0346
Phone: 
(919) 660-1604

Overview

Our work focuses on the design and application of what might best be called novel pulsed techniques, using controlled radiation fields to alter dynamics. The heart of the work is chemical physics, and most of what we do is ultrafast laser spectroscopy or nuclear magnetic resonance. It generally involves an intimate mixture of theory and experiment: recent publications are roughly an equal mix of pencil- and-paper theory, computer calculations with our workstations, and experiments. Collaborations also play an important role, particularly for medical applications.

Education & Training

  • Ph.D., University of California at Berkeley 1980

  • M.S., University of California at Berkeley 1979

Selected Grants

Improving Understanding, Utility and Generality of Hyperpolarized, Long-lived Spin States in Magnetic Resonance awarded by National Science Foundation (Principal Investigator). 2017 to 2020

Making Clinical Scale Hyperpolarization Simple, Fast, and Cheap awarded by National Institutes of Health (Principal Investigator). 2018 to 2020

Making Clinical Scale Hyperpolarization Simple, Fast, and Cheap awarded by National Institutes of Health (Principal Investigator). 2018 to 2020

Probing Hyperpolarized 15N2-diazirine as A Universal Molecular Tag in MRI awarded by National Institutes of Health (Collaborator). 2018 to 2020

Compaction and Sound in Granular Matter awarded by (Principal Investigator). 2015 to 2020

Molecular imaging of in vivo metabolism with a hyperpolarized vitamin shot awarded by North Carolina State University (Principal Investigator). 2019

Molecular imaging of in vivo metabolism with a hyperpolarized vitamin shot awarded by National Institutes of Health (Co Investigator). 2018 to 2019

OP: Collaborative Research: Multimodal Molecular Spectroscopy and Imaging in Biological Tissue and Historical Artwork awarded by National Science Foundation (Co-Principal Investigator). 2016 to 2019

GAANN - Department of Chemistry awarded by Department of Education (Mentor). 2015 to 2019

Training in Medical Imaging awarded by National Institutes of Health (Mentor). 2003 to 2019

Pages

Warren, Warren S. The Physical Basis of Chemistry. Elsevier, 2015.

Wilson, J. W., et al. Imaging pigment chemistry in melanocytic conjunctival lesions with pump-probe microscopy. Vol. 8567, 2013. Scopus, doi:10.1117/12.2003137. Full Text

Lindale, Jacob R., et al. “Decoupled LIGHT-SABRE variants allow hyperpolarization of asymmetric SABRE systems at an arbitrary field..” Journal of Magnetic Resonance (San Diego, Calif. : 1997), vol. 307, Oct. 2019. Epmc, doi:10.1016/j.jmr.2019.106577. Full Text

Zhang, Guannan, et al. “Terminal Diazirines Enable Reverse Polarization Transfer from 15 N2 Singlets..” Angewandte Chemie (International Ed. in English), vol. 58, no. 32, Aug. 2019, pp. 11118–24. Epmc, doi:10.1002/anie.201904026. Full Text

Tanner, Christian P. N., et al. “Selective hyperpolarization of heteronuclear singlet states via pulsed microtesla SABRE..” The Journal of Chemical Physics, vol. 151, no. 4, July 2019. Epmc, doi:10.1063/1.5108644. Full Text

Robles, Francisco E., et al. “Analysis of Melanin Structure and Biochemical Composition in Conjunctival Melanocytic Lesions Using Pump-Probe Microscopy..” Transl Vis Sci Technol, vol. 8, no. 3, May 2019. Pubmed, doi:10.1167/tvst.8.3.33. Full Text

Lindale, Jacob R., et al. “Unveiling coherently driven hyperpolarization dynamics in signal amplification by reversible exchange..” Nature Communications, vol. 10, no. 1, Jan. 2019. Epmc, doi:10.1038/s41467-019-08298-8. Full Text

Ju, Kuk-Youn, et al. “Understanding the Role of Aggregation in the Broad Absorption Bands of Eumelanin..” Acs Nano, vol. 12, no. 12, Dec. 2018, pp. 12050–61. Epmc, doi:10.1021/acsnano.8b04905. Full Text

Bae, Junu, et al. “15N4-1,2,4,5-tetrazines as potential molecular tags: Integrating bioorthogonal chemistry with hyperpolarization and unearthing para-N2..” Science Advances, vol. 4, no. 3, Mar. 2018. Epmc, doi:10.1126/sciadv.aar2978. Full Text

Puza, Charles J., et al. “Correction to: The changing landscape of dermatology practice: melanoma and pump-probe laser microscopy..” Lasers Med Sci, vol. 32, no. 9, Dec. 2017. Pubmed, doi:10.1007/s10103-017-2339-y. Full Text

Shchepin, Roman V., et al. “Spin Relays Enable Efficient Long-Range Heteronuclear Signal Amplification By Reversible Exchange..” The Journal of Physical Chemistry. C, Nanomaterials and Interfaces, vol. 121, no. 51, Dec. 2017, pp. 28425–34. Epmc, doi:10.1021/acs.jpcc.7b11485. Full Text

Shen, Kun, et al. “Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long-Lived SABRE-Induced Hyperpolarization..” Angewandte Chemie (International Ed. in English), vol. 56, no. 40, Sept. 2017, pp. 12112–16. Epmc, doi:10.1002/anie.201704970. Full Text

Pages

Warren, W. S. “Understanding melanoma biochemistry/metastatic potential with pumpprobe microscopy.” Optics Infobase Conference Papers, vol. Part F63-OMP 2017, 2017. Scopus, doi:10.1364/OMP.2017.OmTu2D.1. Full Text

Robles, Francisco E., et al. “Diagnosis and staging of female genital tract melanocytic lesions using pump-probe microscopy (Conference Presentation).” Photonic Therapeutics and Diagnostics Xii, SPIE, 2016. Crossref, doi:10.1117/12.2212949. Full Text

Robles, Francisco E., et al. “Dispersion-based stimulated Raman scattering spectroscopy, holography, and optical coherence tomography (Conference Presentation).” Multiphoton Microscopy in the Biomedical Sciences Xvi, SPIE, 2016. Crossref, doi:10.1117/12.2212875. Full Text

Warren, W. S., et al. “Melanin-targeted nonlinear microscopy for label-free molecular diagnosis and staging.” Optics Infobase Conference Papers, 2016. Scopus, doi:10.1364/TRANSLATIONAL.2016.TTh3B.3. Full Text

Wilson, J. W., et al. “Real-time digital signal processing in multiphoton and time-resolved microscopy.” Progress in Biomedical Optics and Imaging  Proceedings of Spie, vol. 9703, 2016. Scopus, doi:10.1117/12.2218102. Full Text

Villafana, T. E., et al. “Ultrafast pump-probe dynamics of iron oxide based earth pigments for applications to ancient pottery manufacture.” Proceedings of Spie  the International Society for Optical Engineering, vol. 9527, 2015. Scopus, doi:10.1117/12.2184758. Full Text

Wilson, J. W., et al. “Separating higher-order nonlinearities in transient absorption microscopy.” Proceedings of Spie  the International Society for Optical Engineering, vol. 9584, 2015. Scopus, doi:10.1117/12.2187133. Full Text

Wilson, J. W., et al. “In vivo pump-probe microscopy of melanoma: Characterizing shifts in excited state photodynamics with respect to invasiveness.” Progress in Biomedical Optics and Imaging  Proceedings of Spie, vol. 9329, 2015. Scopus, doi:10.1117/12.2079886. Full Text

Warren, W. S. “Enhancing tissue and cultural heritage imaging with ultrafast nonlinear optics.” Optics Infobase Conference Papers, 2014. Scopus, doi:10.1364/PHOTONICS.2016.Tu1A.1. Full Text

Pages