Warren S. Warren

Warren S. Warren

James B. Duke Professor of Chemistry

Professor of Chemistry

Professor of Radiology (Joint)

Professor of Physics (Joint)

Member of the Duke Cancer Institute

Office Location: 
2217 French Science Center, Durham, NC 27708
Front Office Address: 
Box 90346, Durham, NC 27708-0346
Phone: 
(919) 660-1604

Overview

Our work focuses on the design and application of what might best be called novel pulsed techniques, using controlled radiation fields to alter dynamics. The heart of the work is chemical physics, and most of what we do is ultrafast laser spectroscopy or nuclear magnetic resonance. It generally involves an intimate mixture of theory and experiment: recent publications are roughly an equal mix of pencil- and-paper theory, computer calculations with our workstations, and experiments. Collaborations also play an important role, particularly for medical applications.

Education & Training

  • Ph.D., University of California at Berkeley 1980

  • M.S., University of California at Berkeley 1979

Selected Grants

CMBI & NCMA Art Imaging Initiative awarded by (Principal Investigator). 2013 to 2018

Improving Melanoma Diagnosis with Pump-Probe Optical Imaging awarded by National Institutes of Health (Principal Investigator). 2013 to 2017

Coupling the Dynamics of Molecules and Spins in Nuclear Magnetic Resonance for Imaging and Oil Borehole Applications awarded by American Chemical Society (Co-Principal Investigator). 2015 to 2017

Collaborative Research: Development of Novel Nonlinear Optical Contrast for Artwork Imaging awarded by National Science Foundation (Co-Principal Investigator). 2013 to 2017

Multi-modality optical molecular imaging for melanoma tumor margin assessment awarded by National Institutes of Health (Principal Investigator). 2014 to 2017

Sensitive and Specific Molecular Imaging of Pulmonary Nodules awarded by National Institutes of Health (Co Investigator). 2010 to 2016

Structural Biology and Biophysics Training Program awarded by National Institutes of Health (Mentor). 1994 to 2015

Novel Techniques in Nonlinear Optical Microscopy for Improving Melanoma Diagnosis awarded by National Institutes of Health (Principal Investigator). 2013 to 2015

Intermolecular Multiple-Quantum Coherence Effects in MRI awarded by National Institutes of Health (Principal Investigator). 2005 to 2015

Pages

Shchepin, Roman V., et al. “Toward Hyperpolarized 19 F Molecular Imaging via Reversible Exchange with Parahydrogen..” Chemphyschem : A European Journal of Chemical Physics and Physical Chemistry, vol. 18, no. 15, Aug. 2017, pp. 1961–65. Epmc, doi:10.1002/cphc.201700594. Full Text

Wilson, Jesse W., et al. “Comparison of pump-probe and hyperspectral imaging in unstained histology sections of pigmented lesions..” Biomedical Optics Express, vol. 8, no. 8, Aug. 2017, pp. 3882–90. Epmc, doi:10.1364/BOE.8.003882. Full Text

Zhou, Zijian, et al. “Long-Lived 13C2 Nuclear Spin States Hyperpolarized by Parahydrogen in Reversible Exchange at Microtesla Fields..” The Journal of Physical Chemistry Letters, vol. 8, no. 13, July 2017, pp. 3008–14. Epmc, doi:10.1021/acs.jpclett.7b00987. Full Text

Colell, Johannes F. P., et al. “Direct Hyperpolarization of Nitrogen-15 in Aqueous Media with Parahydrogen in Reversible Exchange..” Journal of the American Chemical Society, vol. 139, no. 23, June 2017, pp. 7761–67. Epmc, doi:10.1021/jacs.7b00569. Full Text

Barskiy, Danila A., et al. “The Absence of Quadrupolar Nuclei Facilitates Efficient 13 C Hyperpolarization via Reversible Exchange with Parahydrogen..” Chemphyschem : A European Journal of Chemical Physics and Physical Chemistry, vol. 18, no. 12, June 2017, pp. 1493–98. Epmc, doi:10.1002/cphc.201700416. Full Text

Robles, Francisco E., et al. “Label-Free Imaging of Female Genital Tract Melanocytic Lesions With Pump-Probe Microscopy: A Promising Diagnostic Tool..” J Low Genit Tract Dis, vol. 21, no. 2, Apr. 2017, pp. 137–44. Pubmed, doi:10.1097/LGT.0000000000000290. Full Text

Colell, Johannes F. P., et al. “Generalizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange..” The Journal of Physical Chemistry. C, Nanomaterials and Interfaces, vol. 121, no. 12, Mar. 2017, pp. 6626–34. Epmc, doi:10.1021/acs.jpcc.6b12097. Full Text

Robles, Francisco E., et al. “Stimulated Raman scattering spectroscopic optical coherence tomography..” Optica, vol. 4, no. 2, Feb. 2017, pp. 243–46. Epmc, doi:10.1364/OPTICA.4.000243. Full Text

Thompson, Andrew, et al. “Dual-wavelength pump-probe microscopy analysis of melanin composition..” Scientific Reports, vol. 6, Nov. 2016. Epmc, doi:10.1038/srep36871. Full Text

Warren, Warren S. “Obituary: Ahmed Hassan Zewail (1946-2016)..” Nature, vol. 537, no. 7619, Sept. 2016. Epmc, doi:10.1038/537168a. Full Text

Pages

Degan, Simone, et al. “Abstract 3914:In vivolabel-free examination of early-stage melanoma formation..” Tumor Biology, American Association for Cancer Research, 2013. Crossref, doi:10.1158/1538-7445.am2013-3914. Full Text

Warren, Warren S. “Applications of novel nonlinear imaging: From melanoma diagnosis to art restoration.” Abstracts of Papers of the American Chemical Society, vol. 244, AMER CHEMICAL SOC, 2012.

Samineni, P., et al. “Nonlinear phase contrast imaging in neuronal tissue.” Optics Infobase Conference Papers, 2011.

Matthews, T. E., et al. “Beyond Pathology: Pump-probe imaging of skin slices provides additional indicators of melanoma.” Optics Infobase Conference Papers, 2011.

Warren, W. S. “Tissue imaging with shaped femtosecond laser pulses.” Optics Infobase Conference Papers, 2009.

Song, Jing, and Warren S. Warren. “PHYS 283-Novel magnetic resonance imaging contrast stemming from local resonance frequency variation generated by intermolecular multiple quantum coherences.” Abstracts of Papers of the American Chemical Society, vol. 236, AMER CHEMICAL SOC, 2008.

Warren, Warren S. “PHYS 278-Novel applications and signal enhancement methods for detecting intermolecular multiple quantum coherences in magnetic resonance.” Abstracts of Papers of the American Chemical Society, vol. 236, AMER CHEMICAL SOC, 2008.

Chen, Yuming Morris, and Warren S. Warren. “PHYS 370-Probing local anisotropy using mismatched gradient spin echoes and intermolecular multiple quantum coherences.” Abstracts of Papers of the American Chemical Society, vol. 236, AMER CHEMICAL SOC, 2008.

Galiana, Gigi, et al. “PHYS 363-iMQC-CSI with a single spectroscopic dimension.” Abstracts of Papers of the American Chemical Society, vol. 236, AMER CHEMICAL SOC, 2008.

Branca, Rosa T., et al. “PHYS 355-Amplification of dipolar field effects through binary modulation of equilibrium magnetization.” Abstracts of Papers of the American Chemical Society, vol. 236, AMER CHEMICAL SOC, 2008.

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