Warren S. Warren
James B. Duke Professor of Chemistry
Overview
Our work focuses on the design and application of what might best be called novel pulsed techniques, using controlled radiation fields to alter dynamics. The heart of the work is chemical physics, and most of what we do is ultrafast laser spectroscopy or nuclear magnetic resonance. It generally involves an intimate mixture of theory and experiment: recent publications are roughly an equal mix of pencil- and-paper theory, computer calculations with our workstations, and experiments. Collaborations also play an important role, particularly for medical applications.
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Selected Grants
Improving Understanding, Utility and Generality of Hyperpolarized, Long-lived Spin States in Magnetic Resonance awarded by National Science Foundation (Principal Investigator). 2017 to 2020
Making Clinical Scale Hyperpolarization Simple, Fast, and Cheap awarded by National Institutes of Health (Principal Investigator). 2018 to 2020
Probing Hyperpolarized 15N2-diazirine as A Universal Molecular Tag in MRI awarded by National Institutes of Health (Collaborator). 2018 to 2020
Molecular imaging of in vivo metabolism with a hyperpolarized vitamin shot awarded by National Institutes of Health (Co Investigator). 2018 to 2019
OP: Collaborative Research: Multimodal Molecular Spectroscopy and Imaging in Biological Tissue and Historical Artwork awarded by National Science Foundation (Co-Principal Investigator). 2016 to 2019
GAANN - Department of Chemistry awarded by Department of Education (Mentor). 2015 to 2019
Training in Medical Imaging awarded by National Institutes of Health (Mentor). 2003 to 2019
CMBI & NCMA Art Imaging Initiative awarded by North Carolina Museum of Art (Principal Investigator). 2013 to 2018
Improving Melanoma Diagnosis with Pump-Probe Optical Imaging awarded by National Institutes of Health (Principal Investigator). 2013 to 2017
Coupling the Dynamics of Molecules and Spins in Nuclear Magnetic Resonance for Imaging and Oil Borehole Applications awarded by American Chemical Society (Co-Principal Investigator). 2015 to 2017
Pages
Warren, WS. The Physical Basis of Chemistry.: Elsevier, July 14, 2015.
Wilson, JW, Vajzovic, L, Robles, FE, Cummings, TJ, Mruthyunjaya, P, and Warren, WS. "Imaging pigment chemistry in melanocytic conjunctival lesions with pump-probe microscopy." June 7, 2013. Full Text
Bae, J, Zhou, Z, Theis, T, Warren, WS, and Wang, Q. "15N4-1,2,4,5-tetrazines as potential molecular tags: Integrating bioorthogonal chemistry with hyperpolarization and unearthing para-N2." Science Advances 4.3 (March 9, 2018): eaar2978-null. Full Text
Puza, CJ, Warren, WS, and Mosca, PJ. "Correction to: The changing landscape of dermatology practice: melanoma and pump-probe laser microscopy." Lasers in Medical Science 32.9 (December 2017): 2173-null. Full Text
Shchepin, RV, Jaigirdar, L, Theis, T, Warren, WS, Goodson, BM, and Chekmenev, EY. "Spin Relays Enable Efficient Long-Range Heteronuclear Signal Amplification By Reversible Exchange." The Journal of Physical Chemistry. C, Nanomaterials and Interfaces 121.51 (December 2017): 28425-28434. Full Text
Shen, K, Logan, AWJ, Colell, JFP, Bae, J, Ortiz, GX, Theis, T, Warren, WS, Malcolmson, SJ, and Wang, Q. "Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long-Lived SABRE-Induced Hyperpolarization." Angewandte Chemie (International Ed. in English) 56.40 (September 2017): 12112-12116. Full Text
Wilson, JW, Robles, FE, Deb, S, Warren, WS, and Fischer, MC. "Comparison of pump-probe and hyperspectral imaging in unstained histology sections of pigmented lesions." Biomedical Optics Express 8.8 (August 2017): 3882-3890. Full Text
Shchepin, RV, Goodson, BM, Theis, T, Warren, WS, and Chekmenev, EY. "Toward Hyperpolarized 19 F Molecular Imaging via Reversible Exchange with Parahydrogen." Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry 18.15 (August 2017): 1961-1965. Full Text
Zhou, Z, Yu, J, Colell, JFP, Laasner, R, Logan, A, Barskiy, DA, Shchepin, RV, Chekmenev, EY, Blum, V, Warren, WS, and Theis, T. "Long-Lived 13C2 Nuclear Spin States Hyperpolarized by Parahydrogen in Reversible Exchange at Microtesla Fields." The Journal of Physical Chemistry Letters 8.13 (July 2017): 3008-3014. Full Text
Barskiy, DA, Shchepin, RV, Tanner, CPN, Colell, JFP, Goodson, BM, Theis, T, Warren, WS, and Chekmenev, EY. "The Absence of Quadrupolar Nuclei Facilitates Efficient 13 C Hyperpolarization via Reversible Exchange with Parahydrogen." Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry 18.12 (June 2017): 1493-1498. Full Text
Colell, JFP, Emondts, M, Logan, AWJ, Shen, K, Bae, J, Shchepin, RV, Ortiz, GX, Spannring, P, Wang, Q, Malcolmson, SJ, Chekmenev, EY, Feiters, MC, Rutjes, FPJT, Blümich, B, Theis, T, and Warren, WS. "Direct Hyperpolarization of Nitrogen-15 in Aqueous Media with Parahydrogen in Reversible Exchange." Journal of the American Chemical Society 139.23 (June 2017): 7761-7767. Full Text
Robles, FE, Deb, S, Fischer, MC, Warren, WS, and Selim, MA. "Label-Free Imaging of Female Genital Tract Melanocytic Lesions With Pump-Probe Microscopy: A Promising Diagnostic Tool." Journal of Lower Genital Tract Disease 21.2 (April 2017): 137-144. Full Text
Pages
Warren, WS. "Understanding melanoma biochemistry/metastatic potential with pumpprobe microscopy." January 1, 2017. Full Text
Warren, WS, Robles, F, Fischer, M, Wilson, J, Deb, S, Ju, K, and Degan, S. "Melanin-targeted nonlinear microscopy for label-free molecular diagnosis and staging." April 18, 2016. Full Text
Wilson, JW, Warren, WS, and Fischer, MC. "Real-time digital signal processing in multiphoton and time-resolved microscopy." January 1, 2016. Full Text
Robles, FE, Fischer, MC, and Warren, WS. "Dispersion-based stimulated Raman scattering spectroscopy, holography, and optical coherence tomography (Conference Presentation)." Conference on Multiphoton Microscopy in the Biomedical Sciences XVI. February 14, 2016 - February 16, 2016. San Francisco, CA.: SPIE-INT SOC OPTICAL ENGINEERING, January 1, 2016. Full Text
Robles, FE, Selim, MA, and Warren, WS. "Diagnosis and staging of female genital tract melanocytic lesions using pump-probe microscopy (Conference Presentation)." Conference on Photonic Therapeutics and Diagnostics XII. February 13, 2016 - February 14, 2016. San Francisco, CA.: SPIE-INT SOC OPTICAL ENGINEERING, January 1, 2016. Full Text
Wilson, JW, Degan, S, Gainey, CS, Deb, S, Dall, CP, Tameze-Rivas, Y, Zhang, J, and Warren, WS. "In vivo pump-probe microscopy of melanoma: Characterizing shifts in excited state photodynamics with respect to invasiveness." January 1, 2015. Full Text
Villafana, TE, Brown, W, Warren, WS, and Fischer, M. "Ultrafast pump-probe dynamics of iron oxide based earth pigments for applications to ancient pottery manufacture." January 1, 2015. Full Text
Wilson, JW, Anderson, M, Park, JK, Fischer, MC, and Warren, WS. "Separating higher-order nonlinearities in transient absorption microscopy." January 1, 2015. Full Text
Warren, WS. "Enhancing tissue and cultural heritage imaging with ultrafast nonlinear optics." July 21, 2014. Full Text
Park, JK, Fischer, MC, Susumu, K, Therien, MJ, and Warren, WS. "Femtosecond pulse train shaping for accurate two-photon excited fluorescence measurements." January 1, 2014.