Warren S. Warren

Warren S. Warren

James B. Duke Professor of Chemistry

Office Location: 
2217 French Science Center, Durham, NC 27708
Front Office Address: 
Box 90346, Durham, NC 27708-0346
(919) 660-1604


Our work focuses on the design and application of what might best be called novel pulsed techniques, using controlled radiation fields to alter dynamics. The heart of the work is chemical physics, and most of what we do is ultrafast laser spectroscopy or nuclear magnetic resonance. It generally involves an intimate mixture of theory and experiment: recent publications are roughly an equal mix of pencil- and-paper theory, computer calculations with our workstations, and experiments. Collaborations also play an important role, particularly for medical applications.

Education & Training

  • Ph.D., University of California at Berkeley 1980

  • M.S., University of California at Berkeley 1979

Selected Grants

Improving Understanding, Utility and Generality of Hyperpolarized, Long-lived Spin States in Magnetic Resonance awarded by National Science Foundation (Principal Investigator). 2017 to 2020

Making Clinical Scale Hyperpolarization Simple, Fast, and Cheap awarded by National Institutes of Health (Principal Investigator). 2018 to 2020

Probing Hyperpolarized 15N2-diazirine as A Universal Molecular Tag in MRI awarded by National Institutes of Health (Collaborator). 2018 to 2020

Molecular imaging of in vivo metabolism with a hyperpolarized vitamin shot awarded by National Institutes of Health (Co Investigator). 2018 to 2019

OP: Collaborative Research: Multimodal Molecular Spectroscopy and Imaging in Biological Tissue and Historical Artwork awarded by National Science Foundation (Co-Principal Investigator). 2016 to 2019

GAANN - Department of Chemistry awarded by Department of Education (Mentor). 2015 to 2019

Training in Medical Imaging awarded by National Institutes of Health (Mentor). 2003 to 2019

CMBI & NCMA Art Imaging Initiative awarded by North Carolina Museum of Art (Principal Investigator). 2013 to 2018

Improving Melanoma Diagnosis with Pump-Probe Optical Imaging awarded by National Institutes of Health (Principal Investigator). 2013 to 2017

Coupling the Dynamics of Molecules and Spins in Nuclear Magnetic Resonance for Imaging and Oil Borehole Applications awarded by American Chemical Society (Co-Principal Investigator). 2015 to 2017


Warren, WS. The Physical Basis of Chemistry.: Elsevier, July 14, 2015.

Wilson, JW, Vajzovic, L, Robles, FE, Cummings, TJ, Mruthyunjaya, P, and Warren, WS. "Imaging pigment chemistry in melanocytic conjunctival lesions with pump-probe microscopy.": SPIE. March 26, 2013. Full Text

Lindale, JR, Eriksson, SL, Tanner, CPN, Zhou, Z, Colell, JFP, Zhang, G, Bae, J, Chekmenev, EY, Theis, T, and Warren, WS. "Unveiling coherently driven hyperpolarization dynamics in signal amplification by reversible exchange." Nature Communications 10.1 (January 23, 2019): 395-null. Full Text

Ju, K-Y, Fischer, MC, and Warren, WS. "Understanding the Role of Aggregation in the Broad Absorption Bands of Eumelanin." Acs Nano 12.12 (December 5, 2018): 12050-12061. Full Text

Bae, J, Zhou, Z, Theis, T, Warren, WS, and Wang, Q. "15N4-1,2,4,5-tetrazines as potential molecular tags: Integrating bioorthogonal chemistry with hyperpolarization and unearthing para-N2." Science Advances 4.3 (March 9, 2018): eaar2978-null. Full Text

Puza, CJ, Warren, WS, and Mosca, PJ. "Correction to: The changing landscape of dermatology practice: melanoma and pump-probe laser microscopy." Lasers in Medical Science 32.9 (December 2017): 2173-null. Full Text

Shchepin, RV, Jaigirdar, L, Theis, T, Warren, WS, Goodson, BM, and Chekmenev, EY. "Spin Relays Enable Efficient Long-Range Heteronuclear Signal Amplification By Reversible Exchange." The Journal of Physical Chemistry. C, Nanomaterials and Interfaces 121.51 (December 2017): 28425-28434. Full Text

Shen, K, Logan, AWJ, Colell, JFP, Bae, J, Ortiz, GX, Theis, T, Warren, WS, Malcolmson, SJ, and Wang, Q. "Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long-Lived SABRE-Induced Hyperpolarization." Angewandte Chemie (International Ed. in English) 56.40 (September 2017): 12112-12116. Full Text

Shchepin, RV, Goodson, BM, Theis, T, Warren, WS, and Chekmenev, EY. "Toward Hyperpolarized 19 F Molecular Imaging via Reversible Exchange with Parahydrogen." Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry 18.15 (August 2017): 1961-1965. Full Text

Wilson, JW, Robles, FE, Deb, S, Warren, WS, and Fischer, MC. "Comparison of pump-probe and hyperspectral imaging in unstained histology sections of pigmented lesions." Biomedical Optics Express 8.8 (August 2017): 3882-3890. Full Text

Zhou, Z, Yu, J, Colell, JFP, Laasner, R, Logan, A, Barskiy, DA, Shchepin, RV, Chekmenev, EY, Blum, V, Warren, WS, and Theis, T. "Long-Lived 13C2 Nuclear Spin States Hyperpolarized by Parahydrogen in Reversible Exchange at Microtesla Fields." The Journal of Physical Chemistry Letters 8.13 (July 2017): 3008-3014. Full Text

Colell, JFP, Emondts, M, Logan, AWJ, Shen, K, Bae, J, Shchepin, RV, Ortiz, GX, Spannring, P, Wang, Q, Malcolmson, SJ, Chekmenev, EY, Feiters, MC, Rutjes, FPJT, Blümich, B, Theis, T, and Warren, WS. "Direct Hyperpolarization of Nitrogen-15 in Aqueous Media with Parahydrogen in Reversible Exchange." Journal of the American Chemical Society 139.23 (June 2017): 7761-7767. Full Text


Robles, FE, Selim, MA, and Warren, WS. "Diagnosis and staging of female genital tract melanocytic lesions using pump-probe microscopy (Conference Presentation)." Photonics in Dermatology and Plastic Surgery. February 13, 2016 - February 18, 2016.: SPIE, April 27, 2016. Full Text

Robles, FE, Fischer, MC, and Warren, WS. "Dispersion-based stimulated Raman scattering spectroscopy, holography, and optical coherence tomography (Conference Presentation)." Multiphoton Microscopy in the Biomedical Sciences XVI. February 13, 2016 - February 18, 2016.: SPIE, April 27, 2016. Full Text

Warren, WS, Robles, F, Fischer, M, Wilson, J, Deb, S, Ju, K, and Degan, S. "Melanin-targeted nonlinear microscopy for label-free molecular diagnosis and staging." April 18, 2016. Full Text

Wilson, JW, Degan, S, Gainey, CS, Deb, S, Dall, CP, Tameze-Rivas, Y, Zhang, J, and Warren, WS. "In vivo pump-probe microscopy of melanoma: Characterizing shifts in excited state photodynamics with respect to invasiveness." January 1, 2015. Full Text

Wilson, JW, Anderson, M, Park, JK, Fischer, MC, and Warren, WS. "Separating higher-order nonlinearities in transient absorption microscopy." January 1, 2015. Full Text

Park, JK, Fischer, MC, Susumu, K, Therien, MJ, and Warren, WS. "Femtosecond pulse train shaping for accurate two-photon excited fluorescence measurements." January 1, 2014.