Warren S. Warren
James B. Duke Distinguished Professor of Chemistry
Professor of Chemistry
Professor of Radiology (Joint)
Professor of Physics (Joint)
Member of the Duke Cancer Institute
Overview
Our work focuses on the design and application of what might best be called novel pulsed techniques, using controlled radiation fields to alter dynamics. The heart of the work is chemical physics, and most of what we do is ultrafast laser spectroscopy or nuclear magnetic resonance. It generally involves an intimate mixture of theory and experiment: recent publications are roughly an equal mix of pencil- and-paper theory, computer calculations with our workstations, and experiments. Collaborations also play an important role, particularly for medical applications.
Pages
Selected Grants
Duke Resident Physician-Scientist Program in Radiation Oncology and Radiology awarded by National Institutes of Health (Preceptor). 2020 to 2024
Developing Next-Generation Hyperpolarization Methods for Chemical Analysis awarded by National Science Foundation (Principal Investigator). 2020 to 2023
Medical Scientist Training Program awarded by National Institutes of Health (Mentor). 1997 to 2022
Improving Understanding, Utility and Generality of Hyperpolarized, Long-lived Spin States in Magnetic Resonance awarded by National Science Foundation (Principal Investigator). 2017 to 2021
Making Clinical Scale Hyperpolarization Simple, Fast, and Cheap awarded by National Institutes of Health (Principal Investigator). 2018 to 2021
Probing Hyperpolarized 15N2-diazirine as A Universal Molecular Tag in MRI awarded by National Institutes of Health (Collaborator). 2018 to 2021
Training in Medical Imaging awarded by National Institutes of Health (Mentor). 2003 to 2020
Compaction and Sound in Granular Matter awarded by National Aeronautics and Space Administration (Principal Investigator). 2015 to 2020
Molecular imaging of in vivo metabolism with a hyperpolarized vitamin shot awarded by North Carolina State University (Principal Investigator). 2019
Molecular imaging of in vivo metabolism with a hyperpolarized vitamin shot awarded by National Institutes of Health (Co Investigator). 2018 to 2019
Pages
Warren, Warren S. The Physical Basis of Chemistry. Elsevier, 2015.
Wilson, J. W., et al. Imaging pigment chemistry in melanocytic conjunctival lesions with pump-probe microscopy. Vol. 8567, 2013. Scival, doi:10.1117/12.2003137. Full Text
Colell, Johannes F. P., et al. “Rational ligand choice extends the SABRE substrate scope.” Chemical Communications (Cambridge, England), vol. 56, no. 65, Aug. 2020, pp. 9336–39. Epmc, doi:10.1039/d0cc01330g. Full Text
Yu, Jin, et al. “Visualizing the impact of chloride addition on the microscopic carrier dynamics of MAPbI3 thin films using femtosecond transient absorption microscopy.” The Journal of Chemical Physics, vol. 151, no. 23, AIP Publishing, Dec. 2019, pp. 234710–234710. Crossref, doi:10.1063/1.5127875. Full Text
Lindale, Jacob R., et al. “Decoupled LIGHT-SABRE variants allow hyperpolarization of asymmetric SABRE systems at an arbitrary field.” Journal of Magnetic Resonance (San Diego, Calif. : 1997), vol. 307, Oct. 2019, p. 106577. Epmc, doi:10.1016/j.jmr.2019.106577. Full Text
Zhang, Guannan, et al. “Terminal Diazirines Enable Reverse Polarization Transfer from 15 N2 Singlets.” Angewandte Chemie (International Ed. in English), vol. 58, no. 32, Aug. 2019, pp. 11118–24. Epmc, doi:10.1002/anie.201904026. Full Text
Tanner, Christian P. N., et al. “Selective hyperpolarization of heteronuclear singlet states via pulsed microtesla SABRE.” The Journal of Chemical Physics, vol. 151, no. 4, July 2019, p. 044201. Epmc, doi:10.1063/1.5108644. Full Text
Robles, Francisco E., et al. “Analysis of Melanin Structure and Biochemical Composition in Conjunctival Melanocytic Lesions Using Pump-Probe Microscopy.” Transl Vis Sci Technol, vol. 8, no. 3, May 2019, p. 33. Pubmed, doi:10.1167/tvst.8.3.33. Full Text
Lindale, Jacob R., et al. “Unveiling coherently driven hyperpolarization dynamics in signal amplification by reversible exchange.” Nature Communications, vol. 10, no. 1, Jan. 2019, p. 395. Epmc, doi:10.1038/s41467-019-08298-8. Full Text
Ju, Kuk-Youn, et al. “Understanding the Role of Aggregation in the Broad Absorption Bands of Eumelanin.” Acs Nano, vol. 12, no. 12, American Chemical Society (ACS), Dec. 2018, pp. 12050–61. Crossref, doi:10.1021/acsnano.8b04905. Full Text
Bae, Junu, et al. “15N4-1,2,4,5-tetrazines as potential molecular tags: Integrating bioorthogonal chemistry with hyperpolarization and unearthing para-N2.” Science Advances, vol. 4, no. 3, Mar. 2018, p. eaar2978. Epmc, doi:10.1126/sciadv.aar2978. Full Text
Puza, Charles J., et al. “Correction to: The changing landscape of dermatology practice: melanoma and pump-probe laser microscopy.” Lasers Med Sci, vol. 32, no. 9, Dec. 2017, p. 2173. Pubmed, doi:10.1007/s10103-017-2339-y. Full Text
Pages
Warren, W. S. “Understanding melanoma biochemistry/metastatic potential with pumpprobe microscopy.” Optics Infobase Conference Papers, vol. Part F63-OMP 2017, 2017. Scopus, doi:10.1364/OMP.2017.OmTu2D.1. Full Text
Robles, Francisco E., et al. “Diagnosis and staging of female genital tract melanocytic lesions using pump-probe microscopy (Conference Presentation).” Photonic Therapeutics and Diagnostics Xii, SPIE, 2016. Crossref, doi:10.1117/12.2212949. Full Text
Robles, Francisco E., et al. “Dispersion-based stimulated Raman scattering spectroscopy, holography, and optical coherence tomography (Conference Presentation).” Multiphoton Microscopy in the Biomedical Sciences Xvi, SPIE, 2016. Crossref, doi:10.1117/12.2212875. Full Text
Warren, W. S., et al. “Melanin-targeted nonlinear microscopy for label-free molecular diagnosis and staging.” Optics Infobase Conference Papers, 2016. Scopus, doi:10.1364/TRANSLATIONAL.2016.TTh3B.3. Full Text
Wilson, J. W., et al. “Real-time digital signal processing in multiphoton and time-resolved microscopy.” Progress in Biomedical Optics and Imaging Proceedings of Spie, vol. 9703, 2016. Scopus, doi:10.1117/12.2218102. Full Text
Wilson, J. W., et al. “Separating higher-order nonlinearities in transient absorption microscopy.” Proceedings of Spie the International Society for Optical Engineering, vol. 9584, 2015. Scopus, doi:10.1117/12.2187133. Full Text
Wilson, J. W., et al. “In vivo pump-probe microscopy of melanoma: Characterizing shifts in excited state photodynamics with respect to invasiveness.” Progress in Biomedical Optics and Imaging Proceedings of Spie, vol. 9329, 2015. Scopus, doi:10.1117/12.2079886. Full Text
Villafana, T. E., et al. “Ultrafast pump-probe dynamics of iron oxide based earth pigments for applications to ancient pottery manufacture.” Proceedings of Spie the International Society for Optical Engineering, vol. 9527, 2015. Scopus, doi:10.1117/12.2184758. Full Text
Park, J. K., et al. “Femtosecond pulse train shaping for accurate two-photon excited fluorescence measurements.” Optics Infobase Conference Papers, 2014. Scopus, doi:10.1364/ls.2014.lth4h.3. Full Text
Warren, W. S. “Enhancing tissue and cultural heritage imaging with ultrafast nonlinear optics.” Optics Infobase Conference Papers, 2014. Scopus, doi:10.1364/PHOTONICS.2016.Tu1A.1. Full Text