Martin Fischer

Martin Fischer

Associate Research Professor in the Department of Chemistry

Associate Research Professor of Physics (Secondary)

Faculty Network Member of the Duke Institute for Brain Sciences

Office Location: 
2216 French Science Center, 124 Science Drive, Durham, NC 27708
Front Office Address: 
Box 90346, Durham, NC 27708-0346
Phone: 
(919) 660-1523

Overview

Dr. Fischer’s research focuses on exploring novel nonlinear optical contrast mechanisms for molecular imaging. Nonlinear optical microscopes can provide non-invasive, high-resolution, 3-dimensional images even in highly scattering environments such as biological tissue.

Established contrast mechanisms, such as two-photon fluorescence or harmonic generation, can image a range of targets (such as autofluorescent markers or some connective tissue structure), but many of the most molecularly specific nonlinear interactions are harder to measure with power levels one might be willing to put on tissue. In order to use these previously inaccessible interactions as structural and molecular image contrasts we are developing ultrafast laser pulse shaping and pulse shape detection methods that dramatically enhance measurement sensitivity. Applications of these microscopy methods range from imaging biological tissue (mapping structure, endogenous tissue markers, or exogenous contrast agents) to characterization of nanomaterials (such as graphene and gold nanoparticles). The molecular contrast mechanisms we originally developed for biomedical imaging also provide pigment-specific signatures for paints used in historic artwork. Recently we have demonstrated that we can noninvasively image paint layers in historic paintings and we are currently developing microscopy techniques for use in art conservation and conservation science.

Education & Training

  • Ph.D., University of Texas, Austin 2001

  • M.A., University of Texas, Austin 1993

Villafana, Tana Elizabeth, et al. “Femtosecond pump-probe microscopy generates virtual cross-sections in historic artwork.” Proceedings of the National Academy of Sciences, vol. 111, no. 5, Proceedings of the National Academy of Sciences, Feb. 2014, pp. 1708–13. Crossref, doi:10.1073/pnas.1317230111. Full Text

Fischer, Martin. “Shedding new light on old art.” Physics World, vol. 26, no. 12, IOP Publishing, Dec. 2013, pp. 19–23. Crossref, doi:10.1088/2058-7058/26/12/30. Full Text

Wilson, Jesse W., et al. “Optical clearing of archive-compatible paraffin embedded tissue for multiphoton microscopy: erratum.” Biomedical Optics Express, vol. 4, no. 2, The Optical Society, Feb. 2013, pp. 219–219. Crossref, doi:10.1364/boe.4.000219. Full Text

Li, Baolei, et al. “Direct Optical Imaging of Graphene In Vitro by Nonlinear Femtosecond Laser Spectral Reshaping.” Nano Letters, vol. 12, no. 11, American Chemical Society (ACS), Nov. 2012, pp. 5936–40. Crossref, doi:10.1021/nl303358p. Full Text

Wilson, Jesse W., et al. “Optical clearing of archive-compatible paraffin embedded tissue for multiphoton microscopy.” Biomedical Optics Express, vol. 3, no. 11, The Optical Society, Nov. 2012, pp. 2752–2752. Crossref, doi:10.1364/boe.3.002752. Full Text

Robles, Francisco E., et al. “Phasor analysis for nonlinear pump-probe microscopy.” Optics Express, vol. 20, no. 15, The Optical Society, July 2012, pp. 17082–17082. Crossref, doi:10.1364/oe.20.017082. Full Text

Li, Baolei, et al. “Multicontrast nonlinear optical microscopy with a compact and rapid pulse shaper.” Optics Letters, vol. 37, no. 13, The Optical Society, July 2012, pp. 2763–2763. Crossref, doi:10.1364/ol.37.002763. Full Text

Wilson, Jesse W., et al. “Cross-phase modulation spectral shifting: nonlinear phase contrast in a pump-probe microscope.” Biomedical Optics Express, vol. 3, no. 5, The Optical Society, May 2012, pp. 854–854. Crossref, doi:10.1364/boe.3.000854. Full Text

Samineni, Prathyush, et al. “Pump-probe imaging of historical pigments used in paintings.” Optics Letters, vol. 37, no. 8, The Optical Society, Apr. 2012, pp. 1310–1310. Crossref, doi:10.1364/ol.37.001310. Full Text

Samineni, Prathyush, et al. “Cross-phase modulation imaging.” Optics Letters, vol. 37, no. 5, The Optical Society, Mar. 2012, pp. 800–800. Crossref, doi:10.1364/ol.37.000800. Full Text

Pages

Li, B., et al. “Optimizing shape of femtosecond laser pulses for homodyne detection of nonlinear optical signals.” Optics Infobase Conference Papers, 2011. Scopus, doi:10.1364/fio.2011.ftuq5. Full Text

Samineni, P., et al. “Nonlinear phase contrast imaging in neuronal tissue.” Optics Infobase Conference Papers, 2011. Scopus, doi:10.1364/ntm.2011.nmd3. Full Text

Samineni, P., et al. “Cross-phase modulation microscopy.” Optics Infobase Conference Papers, 2011. Scopus, doi:10.1364/ls.2011.ltua2. Full Text

Samineni, P., et al. “Femtosecond laser pulse shaping improves self-phase modulation measurements in scattering media.” Optics Infobase Conference Papers, 2010.

Li, B., et al. “Enhancing coherent anti-stokes Raman scattering background suppression with phase cycled structured femtosecond laser pulses.” Optics Infobase Conference Papers, 2010. Scopus, doi:10.1364/fio.2010.ftuf2. Full Text

Samineni, P., et al. “Femtosecond laser pulse shaping improves self-phase modulation measurements in scattering media.” Optics Infobase Conference Papers, 2010. Scopus, doi:10.1364/fio.2010.fthg2. Full Text

Warren, W. S., et al. “Nonlinear microscopy without fluorescence: Seeing the needle in the Haystack with Femtosecond pulse shaping.” Optics Infobase Conference Papers, 2009.

Fischer, M. C., et al. “Enhancing two-color absorption, self-phase modulation and raman microscopy signatures in tissue with femtosecond laser pulse shaping.” Progress in Biomedical Optics and Imaging  Proceedings of Spie, vol. 7183, 2009. Scopus, doi:10.1117/12.816488. Full Text

Warren, W. S., et al. “Nonlinear microscopy without fluorescence: Seeing the needle in the Haystack with Femtosecond pulse shaping.” Optics Infobase Conference Papers, 2009. Scopus, doi:10.1364/ntm.2009.nmc1. Full Text

Pages