Associate Research Professor in the Department of Chemistry
Dr. Fischer’s research focuses on exploring novel nonlinear optical contrast mechanisms for molecular imaging. Nonlinear optical microscopes can provide non-invasive, high-resolution, 3-dimensional images even in highly scattering environments such as biological tissue.
Established contrast mechanisms, such as two-photon fluorescence or harmonic generation, can image a range of targets (such as autofluorescent markers or some connective tissue structure), but many of the most molecularly specific nonlinear interactions are harder to measure with power levels one might be willing to put on tissue. In order to use these previously inaccessible interactions as structural and molecular image contrasts we are developing ultrafast laser pulse shaping and pulse shape detection methods that dramatically enhance measurement sensitivity. Applications of these microscopy methods range from imaging biological tissue (mapping structure, endogenous tissue markers, or exogenous contrast agents) to characterization of nanomaterials (such as graphene and gold nanoparticles). The molecular contrast mechanisms we originally developed for biomedical imaging also provide pigment-specific signatures for paints used in historic artwork. Recently we have demonstrated that we can noninvasively image paint layers in historic paintings and we are currently developing microscopy techniques for use in art conservation and conservation science.
Spector, Z. Z., et al. “Quantitative assessment of emphysema using hyperpolarized 3He MRI.” Mag. Res. Med., vol. 53, 2005.
Ye, T., et al. “Two-photon absorption microscopy of tissue.” Optics Infobase Conference Papers, Jan. 2005.
Ishii, Masaru, et al. “Hyperpolarized helium-3 MR imaging of pulmonary function..” Radiol Clin North Am, vol. 43, no. 1, Jan. 2005, pp. 235–46.
Fischer, M. C., et al. “Two-photon absorption and self-phase modulation measurements with shaped femtosecond laser pulses.” Optics Infobase Conference Papers, 2005.
Warren, W. S., et al. “Two-photon absorption imaging with shaped femtosecond laser pulses.” Springer Series in Chemical Physics, vol. 79, Dec. 2004, pp. 867–69.
Ye, T., et al. “Deep tissue imaging approaches by direct capture of two-photon absorption.” 2004 2nd Ieee International Symposium on Biomedical Imaging: Macro to Nano, vol. 1, Dec. 2004, pp. 668–71.
Fischer, M. C., et al. “Single-acquisition sequence for the measurement of oxygen partial pressure by hyperpolarized gas MRI..” Magnetic Resonance in Medicine, vol. 52, no. 4, Oct. 2004, pp. 766–73. Epmc, doi:10.1002/mrm.20239. Full Text
Spector, Z. Z., et al. “A small animal model of regional alveolar ventilation using HP 3He MRI1..” Acad Radiol, vol. 11, no. 10, Oct. 2004, pp. 1171–79. Pubmed, doi:10.1016/j.acra.2004.08.001. Full Text
Soole, J. B. D., et al. “DWDM performance of a packaged reconfigurable optical add-drop multiplexer subsystem supporting modular systems growth.” Ieee Photonics Technology Letters, vol. 15, no. 11, Nov. 2003, pp. 1600–02. Scopus, doi:10.1109/LPT.2003.818673. Full Text
Fischer, M. C., et al. “FEC performance under optical power transient conditions.” Ieee Photonics Technology Letters, vol. 15, no. 11, Nov. 2003, pp. 1654–56. Scopus, doi:10.1109/LPT.2003.818665. Full Text