Martin Fischer

Martin Fischer

Associate Research Professor in the Department of Chemistry

Office Location: 
2216 French Science Center, 124 Science Drive, Durham, NC 27708
Front Office Address: 
Box 90346, Durham, NC 27708-0346
Phone: 
(919) 660-1523

Overview

Dr. Fischer’s research focuses on exploring novel nonlinear optical contrast mechanisms for molecular imaging. Nonlinear optical microscopes can provide non-invasive, high-resolution, 3-dimensional images even in highly scattering environments such as biological tissue.

Established contrast mechanisms, such as two-photon fluorescence or harmonic generation, can image a range of targets (such as autofluorescent markers or some connective tissue structure), but many of the most molecularly specific nonlinear interactions are harder to measure with power levels one might be willing to put on tissue. In order to use these previously inaccessible interactions as structural and molecular image contrasts we are developing ultrafast laser pulse shaping and pulse shape detection methods that dramatically enhance measurement sensitivity. Applications of these microscopy methods range from imaging biological tissue (mapping structure, endogenous tissue markers, or exogenous contrast agents) to characterization of nanomaterials (such as graphene and gold nanoparticles). The molecular contrast mechanisms we originally developed for biomedical imaging also provide pigment-specific signatures for paints used in historic artwork. Recently we have demonstrated that we can noninvasively image paint layers in historic paintings and we are currently developing microscopy techniques for use in art conservation and conservation science.

Education & Training

  • Ph.D., University of Texas at Austin 2001

  • M.A., University of Texas at Austin 1993

Fischer, M. C., et al. “Two-photon absorption and self-phase modulation measurements with shaped femtosecond laser pulses.” Optics Infobase Conference Papers, Jan. 2006.

Warren, W. S., et al. “Deep tissue imaging with shaped femtosecond laser pulses.” Optics Infobase Conference Papers, Jan. 2006.

Ye, T., et al. “Two-photon absorption microscopy of tissue.” Optics Infobase Conference Papers, Jan. 2006.

Kadlecek, S. J., et al. “Imaging physiological parameters with hyperpolarized gas MRI.” Progress in Nuclear Magnetic Resonance Spectroscopy, vol. 47, no. 3–4, Dec. 2005, pp. 187–212. Scopus, doi:10.1016/j.pnmrs.2005.08.006. Full Text

Fischer, M. C., et al. “Two-photon absorption and self-phase modulation measurements with shaped femtosecond laser pulses.” 2005 Conference on Lasers and Electro Optics, Cleo, vol. 2, Dec. 2005, pp. 968–70.

Ye, T., et al. “Two-photon absorption microscopy of tissue.” 2005 Conference on Lasers and Electro Optics, Cleo, vol. 2, Dec. 2005, pp. 1512–14.

Haczku, Angela, et al. “Hyperpolarized 3He MRI in asthma measurements of regional ventilation following allergic sensitization and challenge in mice--preliminary results..” Academic Radiology, vol. 12, no. 11, Nov. 2005, pp. 1362–70. Epmc, doi:10.1016/j.acra.2005.08.027. Full Text

Fischer, Martin C., et al. “Measurements of regional alveolar oxygen pressure using hyperpolarized 3He MRI..” Academic Radiology, vol. 12, no. 11, Nov. 2005, pp. 1430–39. Epmc, doi:10.1016/j.acra.2005.07.007. Full Text

Fischer, Martin C., et al. “Two-photon absorption and self-phase modulation measurements with shaped femtosecond laser pulses..” Optics Letters, vol. 30, no. 12, June 2005, pp. 1551–53. Epmc, doi:10.1364/ol.30.001551. Full Text

Spector, Z. Z., et al. “Quantitative assessment of emphysema using hyperpolarized 3He magnetic resonance imaging..” Magn Reson Med, vol. 53, no. 6, June 2005, pp. 1341–46. Pubmed, doi:10.1002/mrm.20514. Full Text

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