Glenn S. Edwards
Professor of Physics
Overview
Glenn Edwards investigates biological systems using a range of experimental techniques and theoretical methods from physics. His interests include Investigations of energy transduction where laser energy transforms into vibrational energy of biological molecules which then transforms into heat and pressure pulses that selectively drive tissue-scale dynamics. This line of research has led to human surgical applications of Free-Electron Lasers and spin-off laser technology. Another interest includes investigations of how biology harnesses physical mechanisms in biomechanical processes. This line of research investigates tissue dynamics and pattern formation during early development in Drosophila embryos.
Selected Grants
Morphogenesis: Biophysics and Genetics of Dorsal Closure awarded by National Institutes of Health (Co Investigator). 1984 to 2018
Complex Networks: Structure and Function of Large-Scale Neural Networks awarded by Army Research Office (Principal Investigator). 2012 to 2015
Structural Biology and Biophysics Training Program awarded by National Institutes of Health (Mentor). 1994 to 2015
Complex Networks Response to Excitations awarded by Army Research Office (Principal Investigator). 2007 to 2010
Biomedical and Biological Research Applications of a Storage-Ring Free-Electron Laser awarded by Air Force Office of Scientific Research (Principal Investigator). 2000 to 2008
Mathematical Analysis of Non-Stationary Fluctuations awarded by Army Research Office (Principal Investigator). 2003 to 2007
Novel Research Opportunities Using the Duke Storage-Ring FEL awarded by Air Force Office of Scientific Research (Principal Investigator). 2004 to 2006
Center for FEL Research in the Medical, Biological, and Materials Sciences awarded by Air Force Office of Scientific Research (Principal Investigator). 2000 to 2001
Biophysical Research at the Duke FEL Laboratory awarded by Office of Naval Research (Principal Investigator). 1999 to 2000
Infrastructure Support for Light Sources at the Duke FEL Laboratory awarded by Office of Naval Research (Principal Investigator). 1994 to 2000
Pages
Lo, Wei-Chang, et al. “Unified biophysical mechanism for cell-shape oscillations and cell ingression.” Physical Review. E, vol. 97, no. 6–1, June 2018, p. 062414. Epmc, doi:10.1103/physreve.97.062414. Full Text
Kiehart, Daniel P., et al. “Cell Sheet Morphogenesis: Dorsal Closure in Drosophila melanogaster as a Model System.” Annual Review of Cell and Developmental Biology, vol. 33, Oct. 2017, pp. 169–202. Epmc, doi:10.1146/annurev-cellbio-111315-125357. Full Text
Lu, Heng, et al. “Quantifying dorsal closure in three dimensions.” Molecular Biology of the Cell, vol. 27, no. 25, Dec. 2016, pp. 3948–55. Epmc, doi:10.1091/mbc.e16-06-0400. Full Text
Lu, Heng, et al. “Remodeling Tissue Interfaces and the Thermodynamics of Zipping during Dorsal Closure in Drosophila.” Biophysical Journal, vol. 109, no. 11, Dec. 2015, pp. 2406–17. Epmc, doi:10.1016/j.bpj.2015.10.017. Full Text
Wells, Adrienne R., et al. “Complete canthi removal reveals that forces from the amnioserosa alone are sufficient to drive dorsal closure in Drosophila.” Molecular Biology of the Cell, vol. 25, no. 22, Nov. 2014, pp. 3552–68. Epmc, doi:10.1091/mbc.e14-07-1190. Full Text
Sokolow, Adam, et al. “Cell ingression and apical shape oscillations during dorsal closure in Drosophila.” Biophysical Journal, vol. 102, no. 5, Mar. 2012, pp. 969–79. Epmc, doi:10.1016/j.bpj.2012.01.027. Full Text
Layton, Anita T., et al. “Drosophila morphogenesis: tissue force laws and the modeling of dorsal closure.” Hfsp Journal, vol. 3, no. 6, Dec. 2009, pp. 441–60. Epmc, doi:10.2976/1.3266062. Full Text
Edwards, GS. "Mechanisms for soft-tissue ablation and the development of alternative medical lasers based on investigations with mid-infrared free-electron lasers." Laser & Photonics Review 3.6 (November 2, 2009): 545-555. Full Text
Wagner, W., et al. “Thermal vapor bubble and pressure dynamics during infrared laser ablation of tissue.” Applied Physics Letters, vol. 94, no. 1, Jan. 2009. Scopus, doi:10.1063/1.3063127. Full Text
Bush, William D., et al. “Neuromelanins isolated from different regions of the human brain exhibit a common surface photoionization threshold.” Photochemistry and Photobiology, vol. 85, no. 1, Jan. 2009, pp. 387–90. Epmc, doi:10.1111/j.1751-1097.2008.00476.x. Full Text
Pages
Edwards, G., et al. “Partitioning-of-energy model for laser ablation of tissue.” Proceedings of Spie the International Society for Optical Engineering, vol. 2134, 1994, pp. 134–43. Scopus, doi:10.1117/12.182929. Full Text
Mu, R., et al. “Pulsed JR-FEL applications for the characterization of infrared optical materials.” Proceedings of Spie the International Society for Optical Engineering, vol. 2138, 1994, pp. 97–106. Scopus, doi:10.1117/12.181347. Full Text
Edwards, G., et al. “Two years of free-electron laser applications research in biological physics.” Proceedings of Spie the International Society for Optical Engineering, vol. 2138, 1994, pp. 35–40. Scopus, doi:10.1117/12.181340. Full Text
Edwards, G., et al. “Applications of free-electron lasers to measurements of energy transfer in biopolymers and materials.” Proceedings of Spie the International Society for Optical Engineering, vol. 1646, 1992, pp. 13–23. Scopus, doi:10.1117/12.137462. Full Text