Professor of Radiology
Professor of Physics (Secondary)
Professor in the Department of Biomedical Engineering (Secondary)
My research program is focused on developing and applying hyperpolarized gases to enable fundamentally new applications in MRI. Currently we use this technology to non-invasively image pulmonary function in 3D. Hyperpolarization involves aligning nuclei to a high degree to enhance their MRI signal by 5-6 orders of magnitude. Thus, despite the low density of gases relative to water (the ordinary signal source in MRI), they can be imaged at high-resolution in a single breath. This technology leads to a host of interesting areas of study including: investigating the basic physics of hyperpolarization, developing new MR methods and hardware for image acquisition, image analysis and quantification, and of, course applying this technology to a host of chronic diseases including, asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis.
Duke Resident Physician-Scientist Program in Radiation Oncology and Radiology awarded by National Institutes of Health (Preceptor). 2020 to 2024
Duke CTSA (TL1) awarded by National Institutes of Health (Mentor). 2018 to 2023
Early Detection of Changes in Pulmonary Gas Exchange by Hyperpolarized Xe MRI awarded by National Institutes of Health (Principal Investigator). 2011 to 2021
Using MRI To Visualize Regional Therapy Response In Idiopathic Pulmonary Fibrosis awarded by National Institutes of Health (Principal Investigator). 2015 to 2021
Non-invasive Diagnosis of Pulmonary Vascular Disease Using Inhaled 129Xe MRI awarded by National Institutes of Health (Principal Investigator). 2016 to 2020
Utilization of HP 129XE for Diagnosis in Pulmonary Fibrosis awarded by Radiological Society of North America (Advisor). 2018 to 2020
Training in Medical Imaging awarded by National Institutes of Health (Mentor). 2003 to 2020
Detecting ventilation and gas exchange abnormalities by 129Xe MRI in alpha-1 antitrypsin carriers awarded by CSL Behring LLC (Principal Investigator). 2016 to 2019
Human Lung Regional Ventilation Defect Severity Measured by Fluorine-19 Gas MRI awarded by National Institutes of Health (Investigator). 2012 to 2018
Quantitative 129Xe Gas Exchange MRI for Idiopathic Pulmonary Fibrosis awarded by Gilead Sciences, Inc. (Principal Investigator). 2015 to 2017
He, Mu, et al. “Generalized Linear Binning to Compare Hyperpolarized 129Xe Ventilation Maps Derived from 3D Radial Gas Exchange Versus Dedicated Multislice Gradient Echo MRI.” Acad Radiol, vol. 27, no. 8, Aug. 2020, pp. e193–203. Pubmed, doi:10.1016/j.acra.2019.10.016. Full Text Open Access Copy
Virgincar, Rohan S., et al. “Quantitative 129Xe MRI detects early impairment of gas-exchange in a rat model of pulmonary hypertension.” Sci Rep, vol. 10, no. 1, Apr. 2020, p. 7385. Pubmed, doi:10.1038/s41598-020-64361-1. Full Text
Rankine, Leith J., et al. “129Xenon Gas Exchange Magnetic Resonance Imaging as a Potential Prognostic Marker for Progression of Idiopathic Pulmonary Fibrosis.” Ann Am Thorac Soc, vol. 17, no. 1, Jan. 2020, pp. 121–25. Pubmed, doi:10.1513/AnnalsATS.201905-413RL. Full Text
Wang, Ziyi, et al. “Diverse cardiopulmonary diseases are associated with distinct xenon magnetic resonance imaging signatures.” Eur Respir J, vol. 54, no. 6, Dec. 2019. Pubmed, doi:10.1183/13993003.00831-2019. Full Text Open Access Copy
Bier, Elianna A., et al. “A thermally polarized 129 Xe phantom for quality assurance in multi-center hyperpolarized gas MRI studies.” Magn Reson Med, vol. 82, no. 5, Nov. 2019, pp. 1961–68. Pubmed, doi:10.1002/mrm.27836. Full Text
Ebner, Lukas, et al. “Multireader Determination of Clinically Significant Obstruction Using Hyperpolarized 129Xe-Ventilation MRI.” Ajr Am J Roentgenol, vol. 212, no. 4, Apr. 2019, pp. 758–65. Pubmed, doi:10.2214/AJR.18.20036. Full Text
Nouls, John C., et al. “Applications of 3D printing in small animal magnetic resonance imaging.” J Med Imaging (Bellingham), vol. 6, no. 2, Apr. 2019, p. 021605. Pubmed, doi:10.1117/1.JMI.6.2.021605. Full Text
Mammarappallil, Joseph G., et al. “New Developments in Imaging Idiopathic Pulmonary Fibrosis With Hyperpolarized Xenon Magnetic Resonance Imaging.” J Thorac Imaging, vol. 34, no. 2, Mar. 2019, pp. 136–50. Pubmed, doi:10.1097/RTI.0000000000000392. Full Text
Bier, Elianna A., et al. “A protocol for quantifying cardiogenic oscillations in dynamic 129 Xe gas exchange spectroscopy: The effects of idiopathic pulmonary fibrosis.” Nmr Biomed, vol. 32, no. 1, Jan. 2019, p. e4029. Pubmed, doi:10.1002/nbm.4029. Full Text
Wang, Ziyi, et al. “Hyperpolarized 129 Xe gas transfer MRI: the transition from 1.5T to 3T.” Magn Reson Med, vol. 80, no. 6, Dec. 2018, pp. 2374–83. Pubmed, doi:10.1002/mrm.27377. Full Text
Rankine, L., et al. “Disease Progression in Idiopathic Pulmonary Fibrosis: The Potential for Stratifying Patients Using Hyperpolarized Xenon-129 Magnetic Resonance Imaging.” Medical Physics, vol. 46, no. 6, WILEY, 2019, pp. E300–E300.
Fenoli, J., et al. “Comparison of 129Xe-MR Ventilation and 4DCT Ventilation Computed From the Deformation Vector Field.” Medical Physics, vol. 46, no. 6, WILEY, 2019, pp. E246–E246.
Bier, E., et al. “129Xenon MR Imaging and Spectroscopic Signatures to Differentiate Pulmonary Arterial Hypertension from Other Heart and Lung Disease.” American Journal of Respiratory and Critical Care Medicine, vol. 199, AMER THORACIC SOC, 2019.
Mammarappallil, J., et al. “Identification of Gas Exchange Phenotypes Using Hyperpolarized Xe-129 MRI in Patients with Chronic Obstructive Pulmonary Disease (COPD).” American Journal of Respiratory and Critical Care Medicine, vol. 199, AMER THORACIC SOC, 2019.
Coleman, E., et al. “Regional Gas Exchange Function Before and After Glycopyrrolate/Formoterol Fumarate Measured by Hyperpolarized Xe-129 MRI in Chronic Obstructive Lung Disease.” American Journal of Respiratory and Critical Care Medicine, vol. 199, AMER THORACIC SOC, 2019.
Rankine, L., et al. “Dose-Dependent Changes in Regional Lung Function Detected 6-12 Weeks After Radiation Therapy: A Novel Application of Hyperpolarized-129Xe MRI.” Medical Physics, vol. 45, no. 6, WILEY, 2018, pp. E416–17.
Huang, Y. T., et al. “Ventilation and Gas Transfer Distribution in Alpha-1 Antitrypsin Deficiency After Replacement Therapy.” American Journal of Respiratory and Critical Care Medicine, vol. 197, AMER THORACIC SOC, 2018.
Huang, Y. T., et al. “Ventilation and Gas Transfer Measured by 129Xe MRI in Alpha-1 Antitrypsin Heterozygotes: A Pilot Study.” American Journal of Respiratory and Critical Care Medicine, vol. 197, AMER THORACIC SOC, 2018.
Tighe, R. M., et al. “Longitudinal Follow Up After Xe-129 MRI Scan; Potential to Stratify Idiopathic Pulmonary Fibrosis Disease Progression.” American Journal of Respiratory and Critical Care Medicine, vol. 197, AMER THORACIC SOC, 2018.
Rankine, L. J., et al. “Is Lung Ventilation Imaging a Reasonable Surrogate for Gas Exchange? Implications for Functionally Guided Radiation Therapy Planning.” International Journal of Radiation Oncology*Biology*Physics, vol. 99, no. 2, Elsevier BV, 2017, pp. S109–S109. Crossref, doi:10.1016/j.ijrobp.2017.06.258. Full Text