Bastiaan Driehuys

Bastiaan Driehuys

Professor of Radiology

Professor of Physics (Secondary)

Professor in the Department of Biomedical Engineering (Secondary)

Office Location: 
161-B Bryan Research, 311 Research Drive, Durham, NC 27710
Front Office Address: 
Box 3302 Med Ctr, Durham, NC 27710
Phone: 
(919) 684-7786

Overview

My research program is focused on developing and applying hyperpolarized gases to enable fundamentally new applications in MRI. Currently we use this technology to non-invasively image pulmonary function in 3D. Hyperpolarization involves aligning nuclei to a high degree to enhance their MRI signal by 5-6 orders of magnitude. Thus, despite the low density of gases relative to water (the ordinary signal source in MRI), they can be imaged at high-resolution in a single breath. This technology leads to a host of interesting areas of study including: investigating the basic physics of hyperpolarization, developing new MR methods and hardware for image acquisition, image analysis and quantification, and of, course applying this technology to a host of chronic diseases including, asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis.

Education & Training

  • Ph.D., Princeton University 1995

Branca, Rosa T., et al. “Molecular MRI for sensitive and specific detection of lung metastases.Proc Natl Acad Sci U S A, vol. 107, no. 8, Feb. 2010, pp. 3693–97. Pubmed, doi:10.1073/pnas.1000386107. Full Text

Cleveland, Zackary I., et al. “Continuously infusing hyperpolarized 129Xe into flowing aqueous solutions using hydrophobic gas exchange membranes.J Phys Chem B, vol. 113, no. 37, Sept. 2009, pp. 12489–99. Pubmed, doi:10.1021/jp9049582. Full Text

Driehuys, Bastiaan, et al. “Pulmonary perfusion and xenon gas exchange in rats: MR imaging with intravenous injection of hyperpolarized 129Xe.Radiology, vol. 252, no. 2, Aug. 2009, pp. 386–93. Pubmed, doi:10.1148/radiol.2522081550. Full Text

Thomas, Abraham C., et al. “A robust protocol for regional evaluation of methacholine challenge in mouse models of allergic asthma using hyperpolarized 3He MRI.Nmr Biomed, vol. 22, no. 5, June 2009, pp. 502–15. Pubmed, doi:10.1002/nbm.1362. Full Text

Couture, A. H., et al. “Pressure shifts and broadening of the Cs D1 and D2 lines by He, N2, and Xe at densities used for optical pumping and spin exchange polarization.” Journal of Applied Physics, vol. 104, no. 9, Nov. 2008. Scopus, doi:10.1063/1.3018181. Full Text

Brown, Robert H., et al. “An official ATS conference proceedings: advances in small-animal imaging application to lung pathophysiology.Proc Am Thorac Soc, vol. 5, no. 5, July 2008, pp. 591–600. Pubmed, doi:10.1513/pats.200708-116ST. Full Text

Driehuys, Bastiaan, et al. “In vivo MRI using real-time production of hyperpolarized 129Xe.Magn Reson Med, vol. 60, no. 1, July 2008, pp. 14–20. Pubmed, doi:10.1002/mrm.21651. Full Text

Driehuys, Bastiaan, et al. “Small animal imaging with magnetic resonance microscopy.Ilar J, vol. 49, no. 1, 2008, pp. 35–53. Pubmed, doi:10.1093/ilar.49.1.35. Full Text

Driehuys, Bastiaan, et al. “3He MRI in mouse models of asthma.Magn Reson Med, vol. 58, no. 5, Nov. 2007, pp. 893–900. Pubmed, doi:10.1002/mrm.21306. Full Text

Driehuys, Bastiaan, and Laurence W. Hedlund. “Imaging techniques for small animal models of pulmonary disease: MR microscopy.Toxicol Pathol, vol. 35, no. 1, Jan. 2007, pp. 49–58. Pubmed, doi:10.1080/01926230601132048. Full Text

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