Professor of Radiology
Professor of Physics (Secondary)
Professor in the Department of Biomedical Engineering (Secondary)
My research program is focused on developing and applying hyperpolarized gases to enable fundamentally new applications in MRI. Currently we use this technology to non-invasively image pulmonary function in 3D. Hyperpolarization involves aligning nuclei to a high degree to enhance their MRI signal by 5-6 orders of magnitude. Thus, despite the low density of gases relative to water (the ordinary signal source in MRI), they can be imaged at high-resolution in a single breath. This technology leads to a host of interesting areas of study including: investigating the basic physics of hyperpolarization, developing new MR methods and hardware for image acquisition, image analysis and quantification, and of, course applying this technology to a host of chronic diseases including, asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis.
Driehuys, B., et al. “Small animal imaging with magnetic resonance microscopy.” Ilar Journal, vol. 53, no. 1, Sept. 2012, pp. 35–53.
Driehuys, Bastiaan, et al. “Chronic obstructive pulmonary disease: safety and tolerability of hyperpolarized 129Xe MR imaging in healthy volunteers and patients.” Radiology, vol. 262, no. 1, Jan. 2012, pp. 279–89. Pubmed, doi:10.1148/radiol.11102172. Full Text
Cleveland, Zackary I., et al. “In vivo MR imaging of pulmonary perfusion and gas exchange in rats via continuous extracorporeal infusion of hyperpolarized 129Xe.” Plos One, vol. 7, no. 2, 2012, p. e31306. Pubmed, doi:10.1371/journal.pone.0031306. Full Text
Möller, Harald E., et al. “Relaxation of hyperpolarized 129Xe in a deflating polymer bag.” J Magn Reson, vol. 212, no. 1, Sept. 2011, pp. 109–15. Pubmed, doi:10.1016/j.jmr.2011.06.017. Full Text
Thomas, Abe C., et al. “Ventilation defects observed with hyperpolarized 3He magnetic resonance imaging in a mouse model of acute lung injury.” Am J Respir Cell Mol Biol, vol. 44, no. 5, May 2011, pp. 648–54. Pubmed, doi:10.1165/rcmb.2009-0287OC. Full Text
Nouls, John, et al. “A Constant-Volume Ventilator and Gas Recapture System for Hyperpolarized Gas MRI of Mouse and Rat Lungs.” Concepts Magn Reson Part B Magn Reson Eng, vol. 39B, no. 2, Apr. 2011, pp. 78–88. Pubmed, doi:10.1002/cmr.b.20192. Full Text
Kaushik, S. Sivaram, et al. “Diffusion-weighted hyperpolarized 129Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease.” Magn Reson Med, vol. 65, no. 4, Apr. 2011, pp. 1154–65. Pubmed, doi:10.1002/mrm.22697. Full Text
Zheng, Wangzhi, et al. “Gradient-induced longitudinal relaxation of hyperpolarized noble gases in the fringe fields of superconducting magnets used for magnetic resonance.” J Magn Reson, vol. 208, no. 2, Feb. 2011, pp. 284–90. Pubmed, doi:10.1016/j.jmr.2010.11.006. Full Text
Cleveland, Zackary I., et al. “Hyperpolarized Xe MR imaging of alveolar gas uptake in humans.” Plos One, vol. 5, no. 8, Aug. 2010, p. e12192. Pubmed, doi:10.1371/journal.pone.0012192. Full Text Open Access Copy
Mistry, Nilesh N., et al. “Quantitative analysis of hyperpolarized 3He ventilation changes in mice challenged with methacholine.” Magn Reson Med, vol. 63, no. 3, Mar. 2010, pp. 658–66. Pubmed, doi:10.1002/mrm.22311. Full Text