Professor of Radiology
Professor of Physics (Secondary)
Professor in the Department of Biomedical Engineering (Secondary)
My research program is focused on developing and applying hyperpolarized gases to enable fundamentally new applications in MRI. Currently we use this technology to non-invasively image pulmonary function in 3D. Hyperpolarization involves aligning nuclei to a high degree to enhance their MRI signal by 5-6 orders of magnitude. Thus, despite the low density of gases relative to water (the ordinary signal source in MRI), they can be imaged at high-resolution in a single breath. This technology leads to a host of interesting areas of study including: investigating the basic physics of hyperpolarization, developing new MR methods and hardware for image acquisition, image analysis and quantification, and of, course applying this technology to a host of chronic diseases including, asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis.
Cleveland, Zackary I., et al. “3D MRI of impaired hyperpolarized 129Xe uptake in a rat model of pulmonary fibrosis.” Nmr Biomed, vol. 27, no. 12, Dec. 2014, pp. 1502–14. Pubmed, doi:10.1002/nbm.3127. Full Text
He, Mu, et al. “Extending semiautomatic ventilation defect analysis for hyperpolarized (129)Xe ventilation MRI.” Acad Radiol, vol. 21, no. 12, Dec. 2014, pp. 1530–41. Pubmed, doi:10.1016/j.acra.2014.07.017. Full Text
Kaushik, S. Sivaram, et al. “Measuring diffusion limitation with a perfusion-limited gas--hyperpolarized 129Xe gas-transfer spectroscopy in patients with idiopathic pulmonary fibrosis.” J Appl Physiol (1985), vol. 117, no. 6, Sept. 2014, pp. 577–85. Pubmed, doi:10.1152/japplphysiol.00326.2014. Full Text
Freeman, M. S., et al. “Characterizing and modeling the efficiency limits in large-scale production of hyperpolarized 129Xe.” Phys Rev A, vol. 90, no. 2, Aug. 2014, p. 023406. Pubmed, doi:10.1103/physreva.90.023406. Full Text
He, M., et al. “Hyperpolarized 129xe Mri To Quantify Regional Ventilation Differences In Older Versus Younger Asthmatics.” American Journal of Respiratory and Critical Care Medicine, vol. 189, AMER THORACIC SOC, Jan. 2014.
Kaushik, S. S., et al. “Hyperpolarized 129xe Spectroscopy As A Biomarker For Gas-Transfer Impairment In Idiopathic Pulmonary Fibrosis.” American Journal of Respiratory and Critical Care Medicine, vol. 189, AMER THORACIC SOC, Jan. 2014.
Freeman, Matthew S., et al. “Enabling hyperpolarized (129) Xe MR spectroscopy and imaging of pulmonary gas transfer to the red blood cells in transgenic mice expressing human hemoglobin.” Magn Reson Med, vol. 70, no. 5, Nov. 2013, pp. 1192–99. Pubmed, doi:10.1002/mrm.24915. Full Text
Kaushik, S. Sivaram, et al. “Probing the regional distribution of pulmonary gas exchange through single-breath gas- and dissolved-phase 129Xe MR imaging.” J Appl Physiol (1985), vol. 115, no. 6, Sept. 2013, pp. 850–60. Pubmed, doi:10.1152/japplphysiol.00092.2013. Full Text
Virgincar, Rohan S., et al. “Quantitative analysis of hyperpolarized 129Xe ventilation imaging in healthy volunteers and subjects with chronic obstructive pulmonary disease.” Nmr Biomed, vol. 26, no. 4, Apr. 2013, pp. 424–35. Pubmed, doi:10.1002/nbm.2880. Full Text
Cleveland, Z. I., et al. “Detecting Impaired Gas Uptake In A Rat Model Of Pulmonary Fibrosis With 3d Hyperpolarized 129xe Mri.” American Journal of Respiratory and Critical Care Medicine, vol. 187, AMER THORACIC SOC, Jan. 2013.