Bastiaan Driehuys

Bastiaan Driehuys

Professor of Radiology

Professor of Physics (Secondary)

Professor in the Department of Biomedical Engineering (Secondary)

Office Location: 
161-B Bryan Research, 311 Research Drive, Durham, NC 27710
Front Office Address: 
Box 3302 Med Ctr, Durham, NC 27710
Phone: 
(919) 684-7786

Overview

My research program is focused on developing and applying hyperpolarized gases to enable fundamentally new applications in MRI. Currently we use this technology to non-invasively image pulmonary function in 3D. Hyperpolarization involves aligning nuclei to a high degree to enhance their MRI signal by 5-6 orders of magnitude. Thus, despite the low density of gases relative to water (the ordinary signal source in MRI), they can be imaged at high-resolution in a single breath. This technology leads to a host of interesting areas of study including: investigating the basic physics of hyperpolarization, developing new MR methods and hardware for image acquisition, image analysis and quantification, and of, course applying this technology to a host of chronic diseases including, asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis.

Education & Training

  • Ph.D., Princeton University 1995

Selected Grants

Sensitive and Specific Molecular Imaging of Pulmonary Nodules awarded by National Institutes of Health (Principal Investigator). 2010 to 2016

Time-Resolved 129Xe Ventilation-Perfusion MRI in Rat Models of Acute Lung Injury awarded by National Institutes of Health (Mentor). 2012 to 2014

Agilent Direct Drive 9.4T MRS/MRI Console awarded by National Institutes of Health (Major User). 2012 to 2013

Cross-disciplinary Training in Medical Physics awarded by National Institutes of Health (Mentor). 2007 to 2013

Hyperpolarized 129Xe Imaging of Pulmonary Gas Exchange awarded by National Institutes of Health (Principal Investigator). 2007 to 2010

Pages

Virgincar, Rohan S., et al. “A portable ventilator with integrated physiologic monitoring for hyperpolarized 129Xe MRI in rodents.J Magn Reson, vol. 295, Oct. 2018, pp. 63–71. Pubmed, doi:10.1016/j.jmr.2018.07.017. Full Text

Rankine, Leith J., et al. “Correlation of Regional Lung Ventilation and Gas Transfer to Red Blood Cells: Implications for Functional-Avoidance Radiation Therapy Planning.Int J Radiat Oncol Biol Phys, vol. 101, no. 5, Aug. 2018, pp. 1113–22. Pubmed, doi:10.1016/j.ijrobp.2018.04.017. Full Text

Song, Erin J., et al. “Functional airway obstruction observed with hyperpolarized 129 Xenon-MRI.J Med Imaging Radiat Oncol, vol. 62, no. 1, Feb. 2018, pp. 91–93. Pubmed, doi:10.1111/1754-9485.12660. Full Text

Wang, Jennifer M., et al. “Using hyperpolarized 129Xe MRI to quantify regional gas transfer in idiopathic pulmonary fibrosis.Thorax, vol. 73, no. 1, Jan. 2018, pp. 21–28. Pubmed, doi:10.1136/thoraxjnl-2017-210070. Full Text

Robertson, Scott H., et al. “Uncovering a third dissolved-phase 129 Xe resonance in the human lung: Quantifying spectroscopic features in healthy subjects and patients with idiopathic pulmonary fibrosis.Magn Reson Med, vol. 78, no. 4, Oct. 2017, pp. 1306–15. Pubmed, doi:10.1002/mrm.26533. Full Text

Flower, C., et al. “Electron microscopic observations of Rb particles and pitting in 129Xe spin-exchange optical pumping cells.J Appl Phys, vol. 122, no. 2, July 2017, p. 024902. Pubmed, doi:10.1063/1.4991642. Full Text

Mahmood, K., et al. “Novel Magnetic Resonance Imaging for Assessment of Bronchial Stenosis in Lung Transplant Recipients.Am J Transplant, vol. 17, no. 7, July 2017, pp. 1895–904. Pubmed, doi:10.1111/ajt.14287. Full Text

Wang, Ziyi, et al. “Quantitative analysis of hyperpolarized 129 Xe gas transfer MRI.Med Phys, vol. 44, no. 6, June 2017, pp. 2415–28. Pubmed, doi:10.1002/mp.12264. Full Text

House, John S., et al. “Vagal innervation is required for pulmonary function phenotype in Htr4-/- mice.Am J Physiol Lung Cell Mol Physiol, vol. 312, no. 4, Apr. 2017, pp. L520–30. Pubmed, doi:10.1152/ajplung.00495.2016. Full Text

Virgincar, Rohan S., et al. “Establishing an accurate gas phase reference frequency to quantify 129 Xe chemical shifts in vivo.Magn Reson Med, vol. 77, no. 4, Apr. 2017, pp. 1438–45. Pubmed, doi:10.1002/mrm.26229. Full Text

Pages

Nichols, C., et al. “Htr4 Regulates Pulmonary Function Through Neural Innervation.” American Journal of Respiratory and Critical Care Medicine, vol. 195, AMER THORACIC SOC, 2017.

He, M., et al. “Comparing Quantitative 129xe Ventilation Analysis Pipelines Between Mri Centers.” American Journal of Respiratory and Critical Care Medicine, vol. 195, AMER THORACIC SOC, 2017.

He, M., et al. “Characterizing The Ventilation Distribution In Healthy Normal Subjects To Establish Robust Quantitative Analysis Of 129xe Mri.” American Journal of Respiratory and Critical Care Medicine, vol. 193, AMER THORACIC SOC, 2016.

Wang, J. M., et al. “Using Hyperpolarized 129xe Imaging To Quantify Apical Vs. Basal And Central Vs. Peripheral Gas Exchange Impairment In Idiopathic Pulmonary Fibrosis.” American Journal of Respiratory and Critical Care Medicine, vol. 193, AMER THORACIC SOC, 2016.

He, M., et al. “Differentiating Early Stage And Later Stage Ipf Using Hyperpolarized 129xe Ventilation Mri.” American Journal of Respiratory and Critical Care Medicine, vol. 193, AMER THORACIC SOC, 2016.

Cleveland, Z. I., et al. “Probing Diffusive Gas Uptake In Mice Using Hyperpolarized 129xe Magnetic Resonance Spectroscopy And Imaging.” American Journal of Respiratory and Critical Care Medicine, vol. 187, AMER THORACIC SOC, 2013.

Virgincar, R. S., et al. “Quantitative Analysis Of 3he And 1h Mr Images Of Regional Pulmonary Injury In House-Dust-Mite Allergic Mice.” American Journal of Respiratory and Critical Care Medicine, vol. 187, AMER THORACIC SOC, 2013.

Kaushik, S. S., et al. “Reproducibility Of Hyperpolarized 129xe Mri: Alveolar Capillary Gas-Transfer Spectroscopy And Imaging.” American Journal of Respiratory and Critical Care Medicine, vol. 187, AMER THORACIC SOC, 2013.

Driehuys, B., et al. “Hyperpolarized 129Xe MRI for Functional Assessment of Radiation-Induced Lung Injury.” International Journal of Radiation Oncology*Biology*Physics, vol. 63, Elsevier BV, 2005, pp. S460–61. Crossref, doi:10.1016/j.ijrobp.2005.07.784. Full Text

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