Bastiaan Driehuys

Bastiaan Driehuys

Professor of Radiology

Associate Professor of Biomedical Engineering (Secondary)

Professor of Physics (Secondary)

Office Location: 
161-B Bryan Research, 311 Research Drive, Durham, NC 27710
Front Office Address: 
Box 3302 Med Ctr, Durham, NC 27710
Phone: 
(919) 684-7786

Overview

My research program is focused on developing and applying hyperpolarized gases to enable fundamentally new applications in MRI. Currently we use this technology to non-invasively image pulmonary function in 3D. Hyperpolarization involves aligning nuclei to a high degree to enhance their MRI signal by 5-6 orders of magnitude. Thus, despite the low density of gases relative to water (the ordinary signal source in MRI), they can be imaged at high-resolution in a single breath. This technology leads to a host of interesting areas of study including: investigating the basic physics of hyperpolarization, developing new MR methods and hardware for image acquisition, image analysis and quantification, and of, course applying this technology to a host of chronic diseases including, asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis.

Education & Training

  • Ph.D., Princeton University 1995

Möller, H. E., et al. “Magnetic resonance angiography with hyperpolarized 129Xe dissolved in a lipid emulsion.Magn Reson Med, vol. 41, no. 5, May 1999, pp. 1058–64. Pubmed, doi:10.1002/(sici)1522-2594(199905)41:5<1058::aid-mrm26>3.0.co;2-c. Full Text

Möller, H. E., et al. “Sensitivity and resolution in 3D NMR microscopy of the lung with hyperpolarized noble gases.Magn Reson Med, vol. 41, no. 4, Apr. 1999, pp. 800–08. Pubmed, doi:10.1002/(sici)1522-2594(199904)41:4<800::aid-mrm20>3.0.co;2-k. Full Text

Möller, H. E., et al. “Signal dynamics in magnetic resonance imaging of the lung with hyperpolarized noble gases.J Magn Reson, vol. 135, no. 1, Nov. 1998, pp. 133–43. Pubmed, doi:10.1006/jmre.1998.1563. Full Text

Johnson, G. A., et al. “Dynamics of magnetization in hyperpolarized gas MRI of the lung.Magn Reson Med, vol. 38, no. 1, July 1997, pp. 66–71. Pubmed, doi:10.1002/mrm.1910380111. Full Text

Mugler, J. P., et al. “MR imaging and spectroscopy using hyperpolarized 129Xe gas: preliminary human results.Magn Reson Med, vol. 37, no. 6, June 1997, pp. 809–15. Pubmed, doi:10.1002/mrm.1910370602. Full Text

Driehuys, B., et al. “High-volume production of laser-polarized 129Xe.” Applied Physics Letters, vol. 69, no. 12, Sept. 1996, pp. 1668–70. Scopus, doi:10.1063/1.117022. Full Text

MacFall, J. R., et al. “Human lung air spaces: potential for MR imaging with hyperpolarized He-3.Radiology, vol. 200, no. 2, Aug. 1996, pp. 553–58. Pubmed, doi:10.1148/radiology.200.2.8685356. Full Text

Black, R. D., et al. “In vivo He-3 MR images of guinea pig lungs.Radiology, vol. 199, no. 3, June 1996, pp. 867–70. Pubmed, doi:10.1148/radiology.199.3.8638019. Full Text

Driehuys, B., et al. “Surface relaxation mechanisms of laser-polarized 129Xe.Phys Rev Lett, vol. 74, no. 24, June 1995, pp. 4943–46. Pubmed, doi:10.1103/PhysRevLett.74.4943. Full Text

Johnson, J. R., et al. “The SLAC high-density gaseous polarized 3He target.” Nuclear Inst. and Methods in Physics Research, A, vol. 356, no. 1, Mar. 1995, pp. 148–52. Scopus, doi:10.1016/0168-9002(94)01465-5. Full Text

Pages