Bastiaan Driehuys

Bastiaan Driehuys

Professor of Radiology

Associate Professor of Biomedical Engineering (Secondary)

Professor of Physics (Secondary)

Office Location: 
161-B Bryan Research, 311 Research Drive, Durham, NC 27710
Front Office Address: 
Box 3302 Med Ctr, Durham, NC 27710
Phone: 
(919) 684-7786

Overview

My research program is focused on developing and applying hyperpolarized gases to enable fundamentally new applications in MRI. Currently we use this technology to non-invasively image pulmonary function in 3D. Hyperpolarization involves aligning nuclei to a high degree to enhance their MRI signal by 5-6 orders of magnitude. Thus, despite the low density of gases relative to water (the ordinary signal source in MRI), they can be imaged at high-resolution in a single breath. This technology leads to a host of interesting areas of study including: investigating the basic physics of hyperpolarization, developing new MR methods and hardware for image acquisition, image analysis and quantification, and of, course applying this technology to a host of chronic diseases including, asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis.

Education & Training

  • Ph.D., Princeton University 1995

Driehuys, Bastiaan, et al. “Imaging alveolar-capillary gas transfer using hyperpolarized 129Xe MRI.Proc Natl Acad Sci U S A, vol. 103, no. 48, Nov. 2006, pp. 18278–83. Pubmed, doi:10.1073/pnas.0608458103. Full Text

Spector, Z. Z., et al. “Quantitative assessment of emphysema using hyperpolarized 3He magnetic resonance imaging.Magn Reson Med, vol. 53, no. 6, June 2005, pp. 1341–46. Pubmed, doi:10.1002/mrm.20514. Full Text

Spector, Z. Z., et al. “A small animal model of regional alveolar ventilation using HP 3He MRI1.Acad Radiol, vol. 11, no. 10, Oct. 2004, pp. 1171–79. Pubmed, doi:10.1016/j.acra.2004.08.001. Full Text

Månsson, Sven, et al. “Characterization of diffusing capacity and perfusion of the rat lung in a lipopolysaccaride disease model using hyperpolarized 129Xe.Magn Reson Med, vol. 50, no. 6, Dec. 2003, pp. 1170–79. Pubmed, doi:10.1002/mrm.10649. Full Text

Babcock, Earl, et al. “Hybrid spin-exchange optical pumping of 3He.Phys Rev Lett, vol. 91, no. 12, Sept. 2003, p. 123003. Pubmed, doi:10.1103/PhysRevLett.91.123003. Full Text

Jacob, R. E., et al. “Fundamental mechanisms of 3 He relaxation on glass.” Chemical Physics Letters, vol. 370, no. 1–2, Mar. 2003, pp. 261–67. Scopus, doi:10.1016/S0009-2614(03)00110-6. Full Text

Ruppert, K., et al. “NMR of hyperpolarized (129)Xe in the canine chest: spectral dynamics during a breath-hold.Nmr Biomed, vol. 13, no. 4, June 2000, pp. 220–28. Pubmed, doi:10.1002/1099-1492(200006)13:4<220::aid-nbm638>3.0.co;2-f. Full Text

Chen, X. J., et al. “Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part II: T *(2).Magn Reson Med, vol. 42, no. 4, Oct. 1999, pp. 729–37. Pubmed, doi:10.1002/(sici)1522-2594(199910)42:4<729::aid-mrm15>3.0.co;2-2. Full Text

Chen, X. J., et al. “Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: diffusion coefficient.Magn Reson Med, vol. 42, no. 4, Oct. 1999, pp. 721–28. Pubmed, doi:10.1002/(sici)1522-2594(199910)42:4<721::aid-mrm14>3.0.co;2-d. Full Text

Stith, A., et al. “Consequences of (129)Xe-(1)H cross relaxation in aqueous solutions.J Magn Reson, vol. 139, no. 2, Aug. 1999, pp. 225–31. Pubmed, doi:10.1006/jmre.1999.1781. Full Text

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