Bastiaan Driehuys

Bastiaan Driehuys

Professor of Radiology

Office Location: 
161-B Bryan Research, 311 Research Drive, Durham, NC 27710
Front Office Address: 
Box 3302 Med Ctr, Durham, NC 27710
Phone: 
(919) 684-7786

Overview

My research program is focused on developing and applying hyperpolarized gases to enable fundamentally new applications in MRI. Currently we use this technology to non-invasively image pulmonary function in 3D. Hyperpolarization involves aligning nuclei to a high degree to enhance their MRI signal by 5-6 orders of magnitude. Thus, despite the low density of gases relative to water (the ordinary signal source in MRI), they can be imaged at high-resolution in a single breath. This technology leads to a host of interesting areas of study including: investigating the basic physics of hyperpolarization, developing new MR methods and hardware for image acquisition, image analysis and quantification, and of, course applying this technology to a host of chronic diseases including, asthma, chronic obstructive pulmonary disease, and pulmonary fibrosis.

Education & Training

  • Ph.D., Princeton University 1995

Selected Grants

Duke CTSA (KL2) awarded by National Institutes of Health (Mentor). 2018 to 2023

Duke CTSA (TL1) awarded by National Institutes of Health (Mentor). 2018 to 2023

Early Detection of Changes in Pulmonary Gas Exchange by Hyperpolarized Xe MRI awarded by National Institutes of Health (Principal Investigator). 2011 to 2021

Utilization of HP 129XE for Diagnosis in Pulmonary Fibrosis awarded by Radiological Society of North America (Advisor). 2018 to 2020

Using MRI To Visualize Regional Therapy Response In Idiopathic Pulmonary Fibrosis awarded by National Institutes of Health (Principal Investigator). 2015 to 2020

Non-invasive Diagnosis of Pulmonary Vascular Disease Using Inhaled 129Xe MRI awarded by National Institutes of Health (Principal Investigator). 2016 to 2019

Training in Medical Imaging awarded by National Institutes of Health (Mentor). 2003 to 2019

Human Lung Regional Ventilation Defect Severity Measured by Fluorine-19 Gas MRI awarded by National Institutes of Health (Investigator). 2012 to 2018

Quantitative 129Xe Gas Exchange MRI for Idiopathic Pulmonary Fibrosis awarded by (Principal Investigator). 2015 to 2017

Pages

Bier, Elianna A., et al. “A thermally polarized 129 Xe phantom for quality assurance in multi-center hyperpolarized gas MRI studies..” Magn Reson Med, vol. 82, no. 5, Nov. 2019, pp. 1961–68. Pubmed, doi:10.1002/mrm.27836. Full Text

Wang, Ziyi, et al. “Diverse Cardiopulmonary Diseases are Associated with Distinct Xenon MRI Signatures..” Eur Respir J, Oct. 2019. Pubmed, doi:10.1183/13993003.00831-2019. Full Text Open Access Copy

Rankine, Leith J., et al. “129Xenon Gas Exchange MRI as a Potential Prognostic Marker for Progression of Idiopathic Pulmonary Fibrosis..” Ann Am Thorac Soc, Oct. 2019. Pubmed, doi:10.1513/AnnalsATS.201905-413RL. Full Text

He, Mu, et al. “A Comparison of Two Hyperpolarized 129Xe MRI Ventilation Quantification Pipelines: The Effect of Signal to Noise Ratio..” Acad Radiol, vol. 26, no. 7, July 2019, pp. 949–59. Pubmed, doi:10.1016/j.acra.2018.08.015. Full Text

Ebner, Lukas, et al. “Multireader Determination of Clinically Significant Obstruction Using Hyperpolarized 129Xe-Ventilation MRI..” Ajr Am J Roentgenol, vol. 212, no. 4, Apr. 2019, pp. 758–65. Pubmed, doi:10.2214/AJR.18.20036. Full Text

Nouls, John C., et al. “Applications of 3D printing in small animal magnetic resonance imaging..” J Med Imaging (Bellingham), vol. 6, no. 2, Apr. 2019. Pubmed, doi:10.1117/1.JMI.6.2.021605. Full Text

Mammarappallil, Joseph G., et al. “New Developments in Imaging Idiopathic Pulmonary Fibrosis With Hyperpolarized Xenon Magnetic Resonance Imaging..” J Thorac Imaging, vol. 34, no. 2, Mar. 2019, pp. 136–50. Pubmed, doi:10.1097/RTI.0000000000000392. Full Text

Bier, Elianna A., et al. “A protocol for quantifying cardiogenic oscillations in dynamic 129 Xe gas exchange spectroscopy: The effects of idiopathic pulmonary fibrosis..” Nmr Biomed, vol. 32, no. 1, Jan. 2019. Pubmed, doi:10.1002/nbm.4029. Full Text

Wang, Ziyi, et al. “Hyperpolarized 129 Xe gas transfer MRI: the transition from 1.5T to 3T..” Magn Reson Med, vol. 80, no. 6, Dec. 2018, pp. 2374–83. Pubmed, doi:10.1002/mrm.27377. Full Text

Virgincar, Rohan S., et al. “A portable ventilator with integrated physiologic monitoring for hyperpolarized 129Xe MRI in rodents..” J Magn Reson, vol. 295, Oct. 2018, pp. 63–71. Pubmed, doi:10.1016/j.jmr.2018.07.017. Full Text

Pages

Fenoli, J., et al. “Comparison of 129Xe-MR Ventilation and 4DCT Ventilation Computed From the Deformation Vector Field.” Medical Physics, vol. 46, no. 6, WILEY, 2019, pp. E246–E246.

Bier, E., et al. “129Xenon MR Imaging and Spectroscopic Signatures to Differentiate Pulmonary Arterial Hypertension from Other Heart and Lung Disease.” American Journal of Respiratory and Critical Care Medicine, vol. 199, AMER THORACIC SOC, 2019.

Mammarappallil, J., et al. “Identification of Gas Exchange Phenotypes Using Hyperpolarized Xe-129 MRI in Patients with Chronic Obstructive Pulmonary Disease (COPD).” American Journal of Respiratory and Critical Care Medicine, vol. 199, AMER THORACIC SOC, 2019.

Coleman, E., et al. “Regional Gas Exchange Function Before and After Glycopyrrolate/Formoterol Fumarate Measured by Hyperpolarized Xe-129 MRI in Chronic Obstructive Lung Disease.” American Journal of Respiratory and Critical Care Medicine, vol. 199, AMER THORACIC SOC, 2019.

Huang, Y. T., et al. “Ventilation and Gas Transfer Measured by 129Xe MRI in Alpha-1 Antitrypsin Heterozygotes: A Pilot Study.” American Journal of Respiratory and Critical Care Medicine, vol. 197, AMER THORACIC SOC, 2018.

Tighe, R. M., et al. “Longitudinal Follow Up After Xe-129 MRI Scan; Potential to Stratify Idiopathic Pulmonary Fibrosis Disease Progression.” American Journal of Respiratory and Critical Care Medicine, vol. 197, AMER THORACIC SOC, 2018.

Huang, Y. T., et al. “Ventilation and Gas Transfer Distribution in Alpha-1 Antitrypsin Deficiency After Replacement Therapy.” American Journal of Respiratory and Critical Care Medicine, vol. 197, AMER THORACIC SOC, 2018.

Rankine, L. J., et al. “Is Lung Ventilation Imaging a Reasonable Surrogate for Gas Exchange? Implications for Functionally Guided Radiation Therapy Planning.” International Journal of Radiation Oncology*Biology*Physics, vol. 99, no. 2, Elsevier BV, 2017, pp. S109–S109. Crossref, doi:10.1016/j.ijrobp.2017.06.258. Full Text

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