Adam P. Wax

Adam P. Wax

Professor of Biomedical Engineering

Professor of Physics (Secondary)

Faculty Network Member of the Duke Institute for Brain Sciences

Member of the Duke Cancer Institute

Bass Fellow

Office Location: 
2571 CIEMAS, Durham, NC 27708
Front Office Address: 
Box 90281, Durham, NC 27708-0281
(919) 660-5143


Dr. Wax's research interests include optical spectroscopy for early cancer detection, novel microscopy and
interferometry techniques.

The study of intact, living cells with optical spectroscopy offers the opportunity to observe cellular structure, organization and dynamics in a way that is not possible with traditional methods. We have developed a set of novel spectroscopic techniques for measuring spatial, temporal and refractive structure on sub-hertz and sub-wavelength scales based on using low-coherence interferometry (LCI) to detect scattered light. We have applied these techniques in different types of cell biology experiments. In one experiment, LCI measurements of the angular pattern of backscattered light are used to determine non-invasively the structure of sub-cellular organelles in cell monolayers, and the components of epithelial tissue from freshly excised rat esophagus. This work has potential as a diagnostic method for early cancer detection. In another experiment, LCI phase measurements are used to examine volume changes of epithelial cells in a monolayer in response to environmental osmolarity changes. Although cell volume changes have been measured previously, this work demonstrates for the first time the volume of just a few cells (2 or 3) tracked continuously and in situ.

Education & Training

  • Ph.D., Duke University 1999

  • M.A., Duke University 1996

  • B.S., Rensselaer Polytechnic Institute 1993

Braun, K. E., and A. Wax. “Improved simulations for measuring microbicidal gel thickness using low-coherence interferometry.” Optics Infobase Conference Papers, Jan. 2006.

Curry, A. C., and A. Wax. “Sensitivity analysis of detecting plasmon resonance spectral shifts for nanoparticle based biosensors.” Optics Infobase Conference Papers, Jan. 2006.

Chov, D. R., and A. P. Wax. “Optical scattering of confocal laser scanning reflectance microscopy in turbid media.” 2005 Conference on Lasers and Electro Optics, Cleo, vol. 3, Dec. 2005, pp. 1578–80.

Wax, Adam, et al. “Prospective grading of neoplastic change in rat esophagus epithelium using angle-resolved low-coherence interferometry.Journal of Biomedical Optics, vol. 10, no. 5, Sept. 2005, p. 051604. Epmc, doi:10.1117/1.2102767. Full Text

Vo-Dinh, T., et al. “Progress in Biomedical Optics and Imaging - Proceedings of SPIE: Introduction.” Progress in Biomedical Optics and Imaging  Proceedings of Spie, vol. 5692, July 2005.

Graf, R. N., and A. Wax. “Nuclear morphology measurements using Fourier domain low coherence interferometry.” Progress in Biomedical Optics and Imaging  Proceedings of Spie, vol. 5690, July 2005, pp. 460–67. Scopus, doi:10.1117/12.592227. Full Text