Warren S. Warren
James B. Duke Professor of Chemistry
Our work focuses on the design and application of what might best be called novel pulsed techniques, using controlled radiation fields to alter dynamics. The heart of the work is chemical physics, and most of what we do is ultrafast laser spectroscopy or nuclear magnetic resonance. It generally involves an intimate mixture of theory and experiment: recent publications are roughly an equal mix of pencil- and-paper theory, computer calculations with our workstations, and experiments. Collaborations also play an important role, particularly for medical applications.
Multi-modality optical molecular imaging for melanoma tumor margin assessment awarded by National Institutes of Health (Principal Investigator). 2014 to 2017
Novel molecular contrast mechanisms for biomedical applications using pump-probe nonlinear phase dispersion spectroscopy awarded by Burroughs Wellcome Fund (Principal Investigator). 2013 to 2016
Sensitive and Specific Molecular Imaging of Pulmonary Nodules awarded by National Institutes of Health (Co Investigator). 2010 to 2016
Structural Biology and Biophysics Training Program awarded by National Institutes of Health (Mentor). 1994 to 2015
Novel Techniques in Nonlinear Optical Microscopy for Improving Melanoma Diagnosis awarded by National Institutes of Health (Principal Investigator). 2013 to 2015
Intermolecular Multiple-Quantum Coherence Effects in MRI awarded by National Institutes of Health (Principal Investigator). 2005 to 2015
Dynamics and Characterization of Long-Lived Hyperpolarized Molecules in Magnetic Resonance awarded by National Science Foundation (Principal Investigator). 2011 to 2015
Agilent Direct Drive 9.4T MRS/MRI Console awarded by National Institutes of Health (Major User). 2012 to 2013
Novel Magnetic Resonance Approach to Detect BAT Distribution and Temperature awarded by National Institutes of Health (Investigator). 2010 to 2012
Imaging Nonlinear Absorption of Biomarkers for Improved Detection of Melanoma awarded by National Institutes of Health (Principal Investigator). 2009 to 2012
Robles, FE, Zhou, KC, Fischer, MC, and Warren, WS. "Stimulated Raman scattering spectroscopic optical coherence tomography." Optica 4.2 (February 14, 2017): 243-246. Full Text
Thompson, A, Robles, FE, Wilson, JW, Deb, S, Calderbank, R, and Warren, WS. "Dual-wavelength pump-probe microscopy analysis of melanin composition." Scientific reports 6 (November 11, 2016): 36871-. Full Text
Villafana, TE, Delaney, JK, Warren, WS, and Fischer, MC. "High-resolution, three-dimensional imaging of pigments and support in paper and textiles." Journal of Cultural Heritage 20 (July 2016): 583-588. Full Text
Logan, AWJ, Theis, T, Colell, JFP, Warren, WS, and Malcolmson, SJ. "Hyperpolarization of Nitrogen-15 Schiff Bases by Reversible Exchange Catalysis with para-Hydrogen." Chemistry (Weinheim an der Bergstrasse, Germany) 22.31 (July 2016): 10777-10781. Full Text
Barskiy, DA, Shchepin, RV, Coffey, AM, Theis, T, Warren, WS, Goodson, BM, and Chekmenev, EY. "Over 20% (15)N Hyperpolarization in Under One Minute for Metronidazole, an Antibiotic and Hypoxia Probe." Journal of the American Chemical Society 138.26 (July 2016): 8080-8083. Full Text
Shchepin, RV, Barskiy, DA, Coffey, AM, Theis, T, Shi, F, Warren, WS, Goodson, BM, and Chekmenev, EY. "15N Hyperpolarization of Imidazole-15N2 for Magnetic Resonance pH Sensing via SABRE-SHEATH." ACS sensors 1.6 (June 2016): 640-644. Full Text Open Access Copy
Davis, RM, Zhou, Z, Chung, H, and Warren, WS. "Multi-spin echo spatial encoding provides three-fold improvement of temperature precision during intermolecular zero quantum thermometry." Magnetic resonance in medicine 75.5 (May 2016): 1958-1966. Full Text
Theis, T, Ortiz, GX, Logan, AWJ, Claytor, KE, Feng, Y, Huhn, WP, Blum, V, Malcolmson, SJ, Chekmenev, EY, Wang, Q, and Warren, WS. "Direct and cost-efficient hyperpolarization of long-lived nuclear spin states on universal (15)N2-diazirine molecular tags." Science Advances 2.3 (March 25, 2016): e1501438-. Full Text Open Access Copy
Degan, S, Wilson, JW, Gainey, CS, Kent, J, Reddick, TL, Nelson, K, Selim, MA, and Warren, WS. "Abstract 3914: In vivo label-free examination of early-stage melanoma formation." April 15, 2013. Full Text
Warren, WS. "Applications of novel nonlinear imaging: From melanoma diagnosis to art restoration." August 19, 2012.
Samineni, P, Fischer, MC, Liu, HC, Yasuda, R, and Warren, WS. "Nonlinear phase contrast imaging in neuronal tissue." January 1, 2011.
Matthews, TE, Piletic, I, Selim, MA, Simpson, MJ, and Warren, WS. "Beyond Pathology: Pump-probe imaging of skin slices provides additional indicators of melanoma." January 1, 2011.
Galiana, G, Branca, RT, Jenista, ER, and Warren, WS. "PHYS 363-iMQC-CSI with a single spectroscopic dimension." August 17, 2008.
Jenista, ER, Branca, RT, Frank, A, and Warren, WS. "PHYS 361-Hyperpolarized carbon-carbon intermolecular multiple quantum coherences." August 17, 2008.
Song, J, and Warren, WS. "PHYS 283-Novel magnetic resonance imaging contrast stemming from local resonance frequency variation generated by intermolecular multiple quantum coherences." August 17, 2008.
Chen, YM, and Warren, WS. "PHYS 370-Probing local anisotropy using mismatched gradient spin echoes and intermolecular multiple quantum coherences." August 17, 2008.
Branca, RT, Galiana, G, and Warren, WS. "PHYS 355-Amplification of dipolar field effects through binary modulation of equilibrium magnetization." August 17, 2008.