Warren S. Warren

James B. Duke Professor of Chemistry

Office Location: 
2217 French Science Center, Durham, NC 27708
Front Office Address: 
Box 90346, Durham, NC 27708-0346
(919) 660-1604


Our work focuses on the design and application of what might best be called novel pulsed techniques, using controlled radiation fields to alter dynamics. The heart of the work is chemical physics, and most of what we do is ultrafast laser spectroscopy or nuclear magnetic resonance. It generally involves an intimate mixture of theory and experiment: recent publications are roughly an equal mix of pencil- and-paper theory, computer calculations with our workstations, and experiments. Collaborations also play an important role, particularly for medical applications.

Education & Training

  • Ph.D., University of California at Berkeley 1980

  • M.S., University of California at Berkeley 1979

Sensitive and Specific Molecular Imaging of Pulmonary Nodules awarded by National Institutes of Health (Co Investigator). 2010 to 2016

Structural Biology and Biophysics Training Program awarded by National Institutes of Health (Mentor). 1994 to 2015

Novel Techniques in Nonlinear Optical Microscopy for Improving Melanoma Diagnosis awarded by National Institutes of Health (Principal Investigator). 2013 to 2015

Intermolecular Multiple-Quantum Coherence Effects in MRI awarded by National Institutes of Health (Principal Investigator). 2005 to 2015

Dynamics and Characterization of Long-Lived Hyperpolarized Molecules in Magnetic Resonance awarded by National Science Foundation (Principal Investigator). 2011 to 2015

Agilent Direct Drive 9.4T MRS/MRI Console awarded by National Institutes of Health (Major User). 2012 to 2013

Novel Magnetic Resonance Approach to Detect BAT Distribution and Temperature awarded by National Institutes of Health (Investigator). 2010 to 2012

Imaging Nonlinear Absorption of Biomarkers for Improved Detection of Melanoma awarded by National Institutes of Health (Principal Investigator). 2009 to 2012


Warren, WS. "Ahmed Hassan Zewail (1946-2016) OBITUARY." NATURE 537.7619 (September 8, 2016): 168-168.

Warren, WS. "Obituary: Ahmed Hassan Zewail (1946-2016)." Nature 537.7619 (September 7, 2016): 168-. Full Text

Villafana, TE, Delaney, JK, Warren, WS, and Fischer, MC. "High-resolution, three-dimensional imaging of pigments and support in paper and textiles." Journal of Cultural Heritage 20 (July 2016): 583-588. Full Text

Logan, AWJ, Theis, T, Colell, JFP, Warren, WS, and Malcolmson, SJ. "Hyperpolarization of Nitrogen-15 Schiff Bases by Reversible Exchange Catalysis with para-Hydrogen." Chemistry (Weinheim an Der Bergstrasse, Germany) 22.31 (July 2016): 10777-10781. Full Text

Barskiy, DA, Shchepin, RV, Coffey, AM, Theis, T, Warren, WS, Goodson, BM, and Chekmenev, EY. "Over 20% (15)N Hyperpolarization in Under One Minute for Metronidazole, an Antibiotic and Hypoxia Probe." Journal of the American Chemical Society 138.26 (July 2016): 8080-8083. Full Text

Shchepin, RV, Barskiy, DA, Coffey, AM, Theis, T, Shi, F, Warren, WS, Goodson, BM, and Chekmenev, EY. "15N Hyperpolarization of Imidazole-15N2 for Magnetic Resonance pH Sensing via SABRE-SHEATH." ACS sensors 1.6 (June 2016): 640-644. Open Access Copy

Davis, RM, Zhou, Z, Chung, H, and Warren, WS. "Multi-spin echo spatial encoding provides three-fold improvement of temperature precision during intermolecular zero quantum thermometry." Magnetic resonance in medicine 75.5 (May 2016): 1958-1966. Full Text

Theis, T, Ortiz, GX, Logan, AWJ, Claytor, KE, Feng, Y, Huhn, WP, Blum, V, Malcolmson, SJ, Chekmenev, EY, Wang, Q, and Warren, WS. "Direct and cost-efficient hyperpolarization of long-lived nuclear spin states on universal (15)N2-diazirine molecular tags." Science advances 2.3 (March 25, 2016): e1501438-. Full Text Open Access Copy

Fischer, MC, Wilson, JW, Robles, FE, and Warren, WS. "Invited Review Article: Pump-probe microscopy." The Review of scientific instruments 87.3 (March 2016): 031101-. (Review) Full Text

Zhou, Z, Claytor, K, Warren, WS, and Theis, T. "Accessing long lived (1)H states via (2)H couplings." Journal of magnetic resonance (San Diego, Calif. : 1997) 263 (February 2016): 108-115. Full Text


Samineni, P, Fischer, MC, Liu, HC, Yasuda, R, and Warren, WS. "Nonlinear phase contrast imaging in neuronal tissue." January 1, 2011.

Matthews, TE, Piletic, I, Selim, MA, Simpson, MJ, and Warren, WS. "Beyond Pathology: Pump-probe imaging of skin slices provides additional indicators of melanoma." January 1, 2011.

Jenista, ER, Branca, RT, Frank, A, and Warren, WS. "PHYS 361-Hyperpolarized carbon-carbon intermolecular multiple quantum coherences." August 17, 2008.