Warren S. Warren

James B. Duke Professor of Chemistry

External Address: 
2217 French Science Center, Durham, NC 27708
Internal Office Address: 
Box 90346, Durham, NC 27708-0346
(919) 660-1604


Our work focuses on the design and application of what might best be called novel pulsed techniques, using controlled radiation fields to alter dynamics. The heart of the work is chemical physics, and most of what we do is ultrafast laser spectroscopy or nuclear magnetic resonance. It generally involves an intimate mixture of theory and experiment: recent publications are roughly an equal mix of pencil- and-paper theory, computer calculations with our workstations, and experiments. Collaborations also play an important role, particularly for medical applications.

Education & Training

  • Ph.D., University of California at Berkeley 1980

  • M.S., University of California at Berkeley 1979

OP: Collaborative Research: Multimodal Molecular Spectroscopy and Imaging in Biological Tissue and Historical Artwork awarded by National Science Foundation (Co-Principal Investigator). 2016 to 2019

Training in Medical Imaging awarded by National Institutes of Health (Mentor). 2003 to 2019

GAANN - Department of Chemistry awarded by Department of Education (Mentor). 2015 to 2018

CMBI & NCMA Art Imaging Initiative awarded by North Carolina Museum of Art (Principal Investigator). 2013 to 2018

Improving Melanoma Diagnosis with Pump-Probe Optical Imaging awarded by National Institutes of Health (Principal Investigator). 2013 to 2017

Coupling the Dynamics of Molecules and Spins in Nuclear Magnetic Resonance for Imaging and Oil Borehole Applications awarded by American Chemical Society (Co-Principal Investigator). 2015 to 2017

Collaborative Research: Development of Novel Nonlinear Optical Contrast for Artwork Imaging awarded by National Science Foundation (Co-Principal Investigator). 2013 to 2017

Multi-modality optical molecular imaging for melanoma tumor margin assessment awarded by National Institutes of Health (Principal Investigator). 2014 to 2017

Sensitive and Specific Molecular Imaging of Pulmonary Nodules awarded by National Institutes of Health (Co Investigator). 2010 to 2016


Wilson, JW, Vajzovic, L, Robles, FE, Cummings, TJ, Mruthyunjaya, P, and Warren, WS. "Imaging pigment chemistry in melanocytic conjunctival lesions with pump-probe microscopy." 2013. Full Text

Davis, RM, Zhou, Z, Chung, H, and Warren, WS. "Multi-spin echo spatial encoding provides three-fold improvement of temperature precision during intermolecular zero quantum thermometry." Magnetic resonance in medicine 75.5 (May 2016): 1958-1966. Full Text

Theis, T, Ortiz, GX, Logan, AWJ, Claytor, KE, Feng, Y, Huhn, WP, Blum, V, Malcolmson, SJ, Chekmenev, EY, Wang, Q, and Warren, WS. "Direct and cost-efficient hyperpolarization of long-lived nuclear spin states on universal (15)N2-diazirine molecular tags." Science advances 2.3 (March 25, 2016): e1501438-. Full Text Open Access Copy

Crumbliss, AL, Franz, KJ, and Thiele, DJ. "Preface. Biometals 2014--Proceedings of the 9th International Symposium Biometals 2014 at Duke University, Durham, NC, USA." Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 28.3 (June 2015): 431-. Full Text

Shchepin, RV, Truong, ML, Theis, T, Coffey, AM, Shi, F, Waddell, KW, Warren, WS, Goodson, BM, and Chekmenev, EY. "Hyperpolarization of "Neat" Liquids by NMR Signal Amplification by Reversible Exchange." The journal of physical chemistry letters 6.10 (May 8, 2015): 1961-1967. Full Text

Wilson, JW, Degan, S, Gainey, CS, Mitropoulos, T, Simpson, MJ, Zhang, JY, and Warren, WS. "Comparing in vivo pump-probe and multiphoton fluorescence microscopy of melanoma and pigmented lesions." Journal of biomedical optics 20.5 (May 2015): 051012-. Full Text

Truong, ML, Theis, T, Coffey, AM, Shchepin, RV, Waddell, KW, Shi, F, Goodson, BM, Warren, WS, and Chekmenev, EY. "(15)N Hyperpolarization by Reversible Exchange Using SABRE-SHEATH." The journal of physical chemistry. C, Nanomaterials and interfaces 119.16 (April 2015): 8786-8797. Full Text

Wilson, JW, Park, JK, Warren, WS, and Fischer, MC. "Flexible digital signal processing architecture for narrowband and spread-spectrum lock-in detection in multiphoton microscopy and time-resolved spectroscopy." The Review of scientific instruments 86.3 (March 2015): 033707-. Full Text

Theis, T, Truong, ML, Coffey, AM, Shchepin, RV, Waddell, KW, Shi, F, Goodson, BM, Warren, WS, and Chekmenev, EY. "Microtesla SABRE enables 10% nitrogen-15 nuclear spin polarization." Journal of the American Chemical Society 137.4 (February 2015): 1404-1407. Full Text

Davis, RM, and Warren, WS. "Intermolecular zero quantum coherences enable accurate temperature imaging in red bone marrow." Magnetic Resonance in Medicine 74.1 (January 1, 2015): 63-70. Full Text

Theis, T, Truong, M, Coffey, AM, Chekmenev, EY, and Warren, WS. "LIGHT-SABRE enables efficient in-magnet catalytic hyperpolarization." Journal of magnetic resonance (San Diego, Calif. : 1997) 248 (November 2014): 23-26. Full Text


Wilson, JW, Degan, S, Gainey, CS, Deb, S, Dall, CP, Tameze-Rivas, Y, Zhang, J, and Warren, WS. "In vivo pump-probe microscopy of melanoma: Characterizing shifts in excited state photodynamics with respect to invasiveness." January 1, 2015. Full Text

Park, JK, Fischer, MC, Susumu, K, Therien, MJ, and Warren, WS. "Femtosecond pulse train shaping for accurate two-photon excited fluorescence measurements." January 1, 2014.

Matthews, TE, Piletic, I, Selim, MA, Simpson, MJ, and Warren, WS. "Beyond Pathology: Pump-probe imaging of skin slices provides additional indicators of melanoma." January 1, 2011.

Samineni, P, Fischer, MC, Liu, HC, Yasuda, R, and Warren, WS. "Nonlinear phase contrast imaging in neuronal tissue." January 1, 2011.