Nicolas Buchler

Assistant Professor of Biology

Office Location: 
Rm 2353a, CIEMAS Bldg, 101 Science Drive, Duke Box 3382, Durham, NC 27710
Front Office Address: 
Box 90338, 137 Bio Sci, Durham, NC 27708
Phone: 
(919) 660-5701

Overview

Our lab is interested in the systems biology and evolution of epigenetic switches (bistability) and clocks (oscillators) in gene regulatory networks, two functions that are essential for patterning, cell proliferation, and differentiation in biological systems. We also study biochemical oscillators such as the cell cycle, metabolic rhythms, and circadian clocks, which co-exist in the same cells and interact with one another through shared resources.

Education & Training

  • Ph.D., University of Michigan at Ann Arbor 2001

  • M.S., University of Michigan at Ann Arbor 1998

  • B.S., University of California at San Diego 1995

Archambault, V, Buchler, NE, Wilmes, GM, Jacobson, MD, and Cross, FR. "Two-faced cyclins with eyes on the targets." Cell Cycle 4.1 (2005): 125-130.

Buchler, NE, Gerland, U, and Hwa, T. "Nonlinear protein degradation and the function of genetic circuits." Proceedings of the National Academy of Sciences of the United States of America 102.27 (2005): 9559-9564. Full Text

Bintu, L, Buchler, NE, Garcia, HG, Gerland, U, Hwa, T, Kondev, J, Kuhlman, T, and Phillips, R. "Transcriptional regulation by the numbers: Applications." Current Opinion in Genetics and Development 15.2 (2005): 125-135. Full Text

Buchler, NE, Gerland, U, and Hwa, T. "On schemes of combinatorial transcription logic." Proceedings of the National Academy of Sciences of the United States of America 100.9 (2003): 5136-5141. Full Text

Buchler, NEG, and Goldstein, RA. "Surveying determinants of protein structure designability across different energy models and amino-acid alphabets: A consensus." Journal of Chemical Physics 112.5 (2000): 2533-2547.

Buchler, NEG, and Goldstein, RA. "Universal correlation between energy gap and foldability for the random energy model and lattice proteins." Journal of Chemical Physics 111.14 (1999): 6599-6609.

Buchler, NEG, and Goldstein, RA. "Effect of alphabet size and foldability requirements on protein structure designability." Proteins: Structure, Function and Genetics 34.1 (1999): 113-124. Full Text

Buchler, NEG, Zuiderweg, ERP, Wang, H, and Goldstein, RA. "Protein Heteronuclear NMR Assignments Using Mean-Field Simulated Annealing." Journal of Magnetic Resonance 125.1 (1997): 34-42.

Pages